Browsing by Author "Adachi, Isao"

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  • Kato, Atsushi; Kobayashi, Kaori; Narukawa, Kayo; Minoshima, Yuka; Adachi, Isao; Hirono, Shuichi; Nash, Robert J. (2010-10-01)
    We report the structure–activity relationship of a series of coumarins as aldose reductase 2 (ALR2) inhibitors and their suppressive effect on the accumulation of galactitol in the rat lens. We evaluated their ALR2 selectivity ...
  • Kato, Atsushi; Kano, E.; Adachi, Isao; Molyneux, R. J.; Watson, Alison A.; Nash, Robert J.; Fleet, George W. J.; Wormald, M. R.; Kizu, Haruhisa; Ikeda, Kyoko; Asano, Naoki (2003-02-07)
    The first polyhydroxylated pyrrolizidine alkaloid with a hydroxymethyl group at C-3 was isolated from pods of Alexa leiopetala (Leguminosae) and designated alexine 1. The Australian legume Castanospermum australe is also ...
  • Kato, Atsushi; Yasuko, H.; Goto, H.; Hollinshead, Jackie; Nash, Robert J.; Adachi, Isao (2009-03-01)
    Aldose reductase inhibitors have considerable potential for the treatment of diabetic complications, without increased risk of hypoglycemia. Search for components inhibiting aldose reductase led to the discovery of active ...