Browsing by Author "Cannieux, Michel"

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Browsing by Author "Cannieux, Michel"

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  • An old activity in the cytochrome P450 superfamily (CYP51) and a new story of drugs and resistance 
    Kelly, Steven L.; Lamb, David C.; Marczylo, Timothy H.; Jackson, Colin J.; Kelly, Diane E.; Cannieux, Michel; Ugochukwu, C.; Greetham, Darren (2001)
    Cytochrome P450 51 (CYP51) is sterol 14a-demethylase, known also as Erg11p in yeast. First studied in yeast, where it is one of three CYPs in the genome, it has subsequently gained attention as the only CYP found so far ...
  • Plant sterol 14 alpha-demethylase affinity for azole fungicides 
    Lamb, David C.; Kelly, Diane E.; Bak, Soren; Warrilow, Andrew G. S.; Kelly, Steven L.; Cannieux, Michel; Kahn, Rachel A.; Manning, Nigel J. (2001-06-15)
    Azole fungicides were thought to have much greater affinity for the fungal cytochrome P450 enzyme, sterol 14α-demthylase (CYP51) than the plant orthologue. Using purified CYP51 from the plant Sorghum bicolor L Moenech, a ...