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Browsing by Author "Nash, Robert J."

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(2S,3R,4R,5R)-3,4-Dihydroxy-5-hydroxymethyl)pyrrolidine-2-carboxylic acid [(2S,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)proline]

Best, Daniel; Jenkinson, Sarah F.; Thompson, Amber L.; Watkin, David J.; Wilson, Francis X.; Nash, Robert J.; Fleet, George W. J. (2009-09-09)

The crystal structure of the title compound, C(6)H(11)NO(5), establishes the relative configuration at the four stereogenic centres; the absolute configuration is determined by the use of D-glucuronolactone as the starting ...
6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2

Adachi, Isao; Nash, Robert J.; Kobayashi, Kaori; Kato, Atsushi; Hirono, Shuichi; Narukawa, Kayo; Minoshima, Yuka (2010-08-12)

We report the structure–activity relationship of a series of coumarins as aldose reductase 2 (ALR2) inhibitors and their suppressive effect on the accumulation of galactitol in the rat lens. We evaluated their ALR2 selectivity ...
6-oxygenated flavones from Baccharis trinervis (Asteraceae)

Sarker, Satyajit D.; Sharp, Hazel J.; Bright, Colin; Bartholomew, Barbara; Latif, Zahid; Nash, Robert J. (2000-11-02)
Acylated apigenin glycosides from alfalfa (Medicago sativa L.) var. Artal

Macias, Francisco A.; Abreu, Josi M.; Nash, Robert J.; Simonet, Ana M.; Oliveira, Maria A.; Oleszek, Wieslaw; Stochmal, Anna (2001-08)

Three flavones, including 4′-O-[2′-O-E-feruloyl-O-β- -glucuronopyranosyl(1→2)-O-β- -glucuronopyranoside]apigenin, 7-O-β- -glucuronopyranosyl-4′-O-[2′-O-E-feruloyl-O-β- -glucuronopyranosyl(1→2)-O-β- -glucuronopyranoside]apigenin ...
Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae)

Kato, Atsushi; Ikeda, Kyoko; Watson, Alison A.; Haraguchi, M.; Minami, Y.; Asano, Naoki; Nash, Robert J.; Molyneux, R. J.; Gorniak, S. L. (2003-07-11)

Natural intoxication of livestock by the ingestion of Ipomoea carnea (Convolvulaceae) sometimes occurs in tropical regions of the world. Polyhydroxylated alkaloids were isolated from the leaves, flowers, and seeds of the ...
Application of gradient-enhanced nuclear Overhauser effect spectroscopy (GOESY) in the structure elucidation of plant secondary metabolites

Sarker, Satyajit D.; Nash, Robert J.; Latif, Zahid (2001)

Nuclear Overhauser effect (nOe) enhancement plays a vital role in structure determination, especially conformational analysis, by NMR (Neuhaus and Williamson, 1989). A number of one- and two-dimensional NMR methods, notably, ...
Australine and related alkaloids: easy structural confirmation by C-13 NMR spectral data and biological activities

Molyneux, R. J.; Watson, Alison A.; Kato, Atsushi; Kano, E.; al, et; Fleet, George W. J.; Ikeda, Kyoko; Adachi, Isao; Wormald, M. R.; Nash, Robert J.; Kizu, Haruhisa (2003-02-07)

The first polyhydroxylated pyrrolizidine alkaloid with a hydroxymethyl group at C-3 was isolated from pods of Alexa leiopetala (Leguminosae) and designated alexine 1. The Australian legume Castanospermum australe is also ...
The comparative pathology of the glycosidase inhibitors swainsonine, castanospermine and calystegines A3, B2 and C1 in mice

Stegelmeier, B. L.; Molyneux, R. J.; Nash, Robert J.; Asano, M.; Watson, Alison A. (2008)

To study various polyhydroxy-alkaloid glycosidase inhibitors, 16 groups of 3 mice were dosed using osmotic minipumps with swainsonine (0, 0.1, 1, and 10 mg/kg/day), castanospermine, and calystegines A3, B2, and C1 (1, 10, ...
Emodin and syringaldehyde from Rhamnus pubescens (Rhamnaceae)

Thomas, David; Thomas, Barry J.; Bartholomew, Barbara; Sharp, Hazel J.; Nash, Robert J.; Latif, Zahid; Sarker, S. D. (2001)

Rhamnus pubescens Sibth. & Sm. non Poir., originally from Greece, is a European species of Rhamnaceae (PANDORA Taxonomic Database System, 1999. Flora Europaea. Royal Botanic Garden Edinburgh, UK. Available on line at: ...
Fungal endophytes in a sand dune plant: effects on nematodes

Nash, Robert J.; Cook, Roger; Hol, W. H. Gera (2005)
Iminosugars from Baphia mitida Lodd

Kato, Atsushi; Kato, Noriko; Miyauchi, Saori; Minoshima, Yuka; Adachi, Isao; Ikeda, Kyoko; Asano, Naoki; Watson, Alison A.; Nash, Robert J. (2008-03)

Chromatographic separation of the 50% aqueous EtOH extract of the leaves of the African medicinal tree Baphia nitida resulted in isolation of 10 iminosugars. The plant contained 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine ...
Inhibitory effects of Zingiber officinale roscoe derived components on aldose reductase activity in vitro and in vivo

Kato, Atsushi; Nash, Robert J.; Asano, Naoki; Okamoto, T.; Kizu, Haruhisa; Higuchi, Y.; Adachi, Isao; Goto, H.; Hollinshead, Jackie (2006-08-05)

Ginger (Zingiber officinale Roscoe) continues to be used as an important cooking spice and herbal medicine around the world. Scientific research has gradually verified the antidiabetic effects of ginger. Especially gingerols, ...
Intramolecular guanidine epoxide ring opening reactions

Winters, Ana L.; Dennis, M.; Horton, P.; Murphy, P. J.; Thornhill, A. J.; Hall, L. M.; Hursthouse, M. B.; Nash, Robert J.; Light, M. E. (2003-04-07)

The synthesis of a range of cyclic guanidines via intramolecular ring opening of epoxides or iodocyclisation is reported. A preliminary investigation of the glycosidase inhibitory activity of these substances is also ...
Isolation of the pyrrolizidine alkaloid 1-epialexine from Castanospermum australe

Jones, Laurence; Hollinshead, Jackie; Fleet, George W. J.; Thompson, Amber L.; Watkin, David J.; Gal, Zoltan A.; Jenkinson, Sarah F.; Kato, Atsushi; Nash, Robert J. (2010-09)

The Australian leguminous tree Castanospermum australe contains the anti-viral glucose analogue indolizidine alkaloid castanospermine. As the result of a search for new bioactive carbohydrate-like compounds we now report ...
Isolation synthesis and glycosidase inhibition profile of 3-epi-casuarine

Nash, Robert J.; Evinson, Emma L.; Horne, Graeme; Fleet, George W. J.; Dwek, R. A.; Ameijde, Jeroen V.; Jones, Paul W.; Wormald, M. R. (2006-10-31)

3-epi-Casuarine, the first naturally occurring stereoisomer of casuarine, was isolated from Myrtus communis L. The glycosidase inhibition profile and NMR spectra of 3-epi-casuarine are compared with those of casuarine; the ...
Lignans from Cupressus lusitanica (Cupressaceae)

Cowan, S.; Nash, Robert J.; Latif, Zahid; Sarker, S. D.; Watson, Alison A.; Bartholomew, Barbara; Bright, Colin (2001-01)

Cupressus lusitanica Mill. (Family: Cupressaceae), commonly known as ‘Mexican cypress’ or ‘Cedar-of-Goa', is an ornamental plant found extensively in Mexico, El Salvador, Guatemala and Honduras, and also in other parts of ...
Lignans from Strophanthus gratus

Sarker, S. D.; Latif, Zahid; Cowan, S.; Abbiw, D. K.; Stewart, M.; Nash, Robert J. (2001-01)

Three lignans, pinoresinol 1., 8-hydroxypinoresinol 2. and olivil 3. have been isolated from the leaves of Strophanthus gratus by reversed-phase HPLC.
Looking glass inhibitors : both enantiomeric N-benzyl derivatives of 1,4-dideoxy-1,4-imino-D-lyxitol [a potent competitive inhibitor of alpha-D-galactosidase] and of 1,4-dideoxy-1,4-imino-L-lyxitol [a weak competitive inhibitor of alpha-D-galactosidase] inhibit naringinase, an alpha-L-rhamnosidase competitively

Mercer, Thomas B.; Jenkinson, Sarah F.; Bartholomew, Barbara; Nash, Robert J.; Miyauchi, Saori; Kato, Atsushi; Fleet, George W. J. (2009-10-20)

Benzhydryl protection by diphenyldiazomethane of an alcohol in enantiomeric base-sensitive ribonolactones allows short efficient syntheses of 1,4-dideoxy-1,4-imino-D-lyxitol (DIL) and of 1,4-dideoxy-1,4-imino-L-lyxitol ...
Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP

Nash, Robert J.; Asano, Naoki; Winters, Ana L.; Yu, C. Y.; Fleet, George W. J.; Butters, T. D.; Ikeda, Kyoko; Dwek, R. A.; Wormald, M. R.; Wang, M. X. (2004-07-29)

L-DMDP, prepared from D-gulonolactone, is a highly specific inhibitor of a number of plant and mammalian -glucosidases [between 2 and 4 orders of magnitude more potent than the enantiomeric natural product DMDP] but is not ...
Non-protein amino acids: a review of the biosynthesis and taxonomic significance

Bell, E. A.; Nash, Robert J.; Watson, Alison A. (2008)

The non-protein amino acids, with which we are concerned here, are not incorporated into the proteins of the organisms that synthesize them nor are their residues formed by the post-translational modification of protein ...

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