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Browsing by Author "Vaidyanathan, S."

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Assessment of near-infrared spectral information for rapid monitoring of bioprocess quality

Harvey, Linda M.; McNeil, B.; Vaidyanathan, S.; Mohan, P.; Arnold, S. A.; Matheson, L. (2001-09-05)

Access to real-time process information is desirable for consistent and efficient operation of bioprocesses. Near-infrared spectroscopy (NIRS) is known to have potential for providing real-time information on the quantitative ...
Deconvolution of near-infrared spectral information for monitoring mycelial biomass and other key analytes in a submerged fungal bioprocess

McNeil, B.; Harvey, Linda M.; Vaidyanathan, S. (2001-02-01)

Near-infrared spectroscopy is a promising technique for the rapid monitoring of submerged culture bioprocesses. However, despite the key role of mycelial (filamentous fungal and bacterial) micro-organisms in the manufacture ...
Discrimination of aerobic endospore-forming bacteria via electrospray-ionization mass spectrometry of whole cell suspensions

Kell, Douglas B.; Goodacre, Royston; Rowland, Jem; Vaidyanathan, S. (2001-08-02)

Direct injection electrospray ionization mass spectrometry (ESI-MS) without prior analyte separation was investigated for the analysis of whole cell suspensions of bacteria. Thirty-six strains of aerobic endospore-forming ...
Explanatory optimization of protein mass spectrometry via genetic search

Goodacre, Royston; Vaidyanathan, S.; Broadhurst, David I.; Kell, Douglas B. (2003-10-25)

Optimizing experimental conditions for the effective analysis of intact proteins by mass spectrometry is challenging, as many analytical factors influence the spectral quality, often in very different ways for different ...
Laser desorption/ionization mass spectrometry on porous silicon for metabolome analyses: influence of surface oxidation

Jones, D. G.; Vaidyanathan, S.; Jenkins, Tudor; Ellis, J. (2007-07-15)

Laser desorption/ionization mass spectrometry (LDI-MS) on porous silicon is a promising analytical strategy for the rapid detection of metabolites in biological matrices. We show that both oxidized and unoxidized porous ...

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