Browsing by Author "Warrilow, Andrew G. S."

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  • Venkateswarlu, K.; Lamb, David Christopher; Warrilow, Andrew G. S.; Kelly, Diane Elizabeth; Kelly, Steven Lewis (2001-08-10)
    Native yeast NADPH–cytochrome P450 oxidoreductase (CPR; EC 1.6.2.4) and a soluble derivative lacking 33 amino acids of the NH2-terminus have been overexpressed as recombinant proteins in Escherichia coli. The presence of ...
  • Kelly, Steven Lewis; Lamb, David Christopher; Jackson, Colin J.; Warrilow, Andrew G. S.; Kelly, Diane Elizabeth (Reed Elsevier, 2003)
    The cytochrome P450 (CYP) superfamily of genes and proteins are well known for their involvement in pharmacology and toxicology, but also increasingly for their importance and diversity in microbes. The extent of diversity ...
  • Marczylo, Timothy H.; Kelly, Diane Elizabeth; Kelly, Steven Lewis; Lamb, David Christopher; Lowe, David J.; Manning, Nigel J.; Warrilow, Andrew G. S.; Jackson, Colin J. (2002-09-06)
    Sterol 14α-demethylase encoded by CYP51 is a member of the cytochrome P450 (CYP) superfamily of enzymes and has been shown to have an essential role in sterol biosynthesis in eukaryotes, with orthologues recently being ...
  • Kelly, Steven Lewis; Lamb, David Christopher; Warrilow, Andrew G. S.; Kelly, Diane Elizabeth (2002-11-29)
    The recently completed genome of the basidiomycete, Phanerochaete chrysosporium, revealed the presence of one NADPH-cytochrome P450 oxidoreductase (CPR; EC 1.6.2.4) gene and >123 cytochrome P450 (CYP) genes. How a single ...
  • Lamb, David Christopher; Kelly, Diane Elizabeth; Bak, Soren; Warrilow, Andrew G. S.; Kelly, Steven Lewis; Cannieux, Michel; Kahn, Rachel A.; Manning, Nigel J. (2001-06-15)
    Azole fungicides were thought to have much greater affinity for the fungal cytochrome P450 enzyme, sterol 14α-demthylase (CYP51) than the plant orthologue. Using purified CYP51 from the plant Sorghum bicolor L Moenech, a ...