Browsing by Subject "metabolomics"

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  • Beckmann, Manfred; Joosen, Annemiek M.; Clarke, Michelle M.; Mugridge, Owen; Frost, Gary; Engel, Barbara; Tailliart, Kathleen; Lloyd, Amanda; Draper, John; Lodge, John K. (2016-02-01)
    Scope The intake of sucrose is of public health concern but limited information is available on the metabolic effects of short-term exposure. Our aim was to use metabolomics to investigate the metabolic impact of acute ...
  • Lloyd, Amanda; Beckmann, Manfred; Tailliart, Kathleen; Brown, Wendy Y.; Draper, John; Allaway, David (2016-03-08)
    Introduction Dog breeds are a consequence of artificial selection for specific attributes. These closed genetic populations have metabolic and physiological characteristics that may be revealed by metabolomic analysis. ...
  • Jones, Arwel W.; Cameron, Simon J. S.; Thatcher, Rhys; Beecroft, Marikka Shannon; Mur, Luis A. J.; Davison, Glen (2014-07)
    Bovine colostrum (COL) has been advocated as a nutritional countermeasure to exercise-induced immune dysfunction and increased risk of upper respiratory illness (URI) in athletic populations, however, the mechanisms remain ...
  • Draper, J.; Rasmussen, S.; Zubair, H. (Wiley, 2011-03-17)
    Biotrophic plant-microbe interactions depend on the establishment of a nutritional interface allowing nutrient trafficking between plants and microbial symbionts and pathogens. A global re-programming of host and microbial ...
  • Lloyd, Amanda Jane; Allwood, James William; Winder, Catherine L; Dunn, Warwick B; Heald, James Kevin; Cristescu, Simona M; Sivakumaran, Anushen; Harren, Frans J M; Mulema, Joseph; Denby, Katherine; Goodacre, Royston; Smith, Aileen R; Mur, Luis Alejandro Jose (2011-09)
    In Arabidopsis, resistance to the necrotrophic fungus Botrytis cinerea is conferred by ethylene via poorly understood mechanisms. Metabolomic approaches compared the responses of the wild-type, the ethylene-insensitive ...
  • Cameron, Simon; Lewis, Keir E.; Beckmann, Manfred; Allison, Gordon; Ghosal, Robin; Lewis, Paul D.; Mur, Luis (2016-04)
    Objectives Developing screening and diagnosis methodologies based on novel biomarkers should allow for the detection of the lung cancer (LC) and possibly at an earlier stage and thereby increase the effectiveness of clinical ...
  • Sanchez-Martin, Javier; Heald, Jim; Kingston-Smith, Alison; Winters, Ana; Rubiales, Diego; Sanz, Mariluz; Mur, Luis; Prats, Elena (2014)
    Although a wealth of information is available on the induction of one or several drought related responses in different species, little is known of how their timing, modulation and crucially integration influence drought ...
  • O'Shea, Keiron; Cameron, Simon J S; Lewis, Keir E; Lu, Chuan; Mur, Luis A J (2016-07-14)
    BACKGROUND: Lung cancer (LC) is one of the leading lethal cancers worldwide, with an estimated 18.4% of all cancer deaths being attributed to the disease. Despite developments in cancer diagnosis and treatment over the ...
  • Fiehn, Oliver; Robertson, Donald; Griffin, Julian L.; van der Werf, Mariet; Nikolau, Basil; Morrison, Norman; Sumner, Lloyd W.; Goodacre, Royston; Hardy, Nigel; Taylor, Chris F.; Fostel, Jennifer; Kristal, Bruce; Kaddurah-Daouk, Rima; Mendes, Pedro; van Ommen, B.; Lindon, John C.; Sansone, Susanna-Assunta (2007-09-01)
    In 2005, the Metabolomics Standards Initiative has been formed. An outline and general introduction is provided to inform about the history, structure, working plan and intentions of this initiative. Comments on any of the ...
  • Scott, Ian Morris; Ward, Jane L.; Miller, Sonia J.; Beale, Michael H. (2014-11-20)
    In chilling conditions (5°C), salicylic acid (SA)-deficient mutants (sid2, eds5 and NahG) of Arabidopsis thaliana produced more biomass than wild type (Col-0), whereas the SA overproducer cpr1 was extremely stunted. The ...
  • Sumner, Lloyd W.; Amberg, Alexander; Barrett, Dave; Beale, Michael H.; Beger, Richard; Daykin, Clare; Fan, Teresa; Fiehn, Oliver; Goodacre, Royston; Griffin, Julian L.; Hankemeier, Thomas; Hardy, Nigel; Harnly, James; Higashi, Richard; Kopka, Joachim; Lane, Andrew N.; Lindon, John C.; Marriott, Philip; Nicholls, Andrew W.; Reily, Michael D.; Thaden, John J.; Viant, Mark R. (2007-09-01)
    There is a general consensus that supports the need for standardized reporting of metadata or information describing large-scale metabolomics and other functional genomics data sets. Reporting of standard metadata provides ...
  • Rubtsov, Denis V.; Jenkins, Helen; Ludwig, Christian; Easton, John; Viant, Mark R.; Günther, Ulrich; Griffin, Julian L.; Hardy, Nigel (2007-09-01)
    The amount of data generated by NMR-based metabolomic experiments is increasing rapidly. Furthermore, diverse techniques increase the need for informative and comprehensive meta-data. These factors present a challenge in ...
  • Jenkins, Helen; Kular, Baldeep; Johnson, Helen E.; Wang, Trevor; Hardy, Nigel (2006-03-16)
    Over recent years, a number of initiatives have proposed standard reporting guidelines for functional genomics experiments. Associated with these are data models that may be used as the basis of the design of software tools ...
  • Jenkins, Helen; Johnson, Helen Elisabeth; Kular, Baldeep; Wang, Trevor; Hardy, Nigel (2005-05-11)
    Over recent years, a number of initiatives have proposed standard reporting guidelines for functional genomics experiments. Associated with these are data models that may be used as the basis of the design of software tools ...
  • Primrose, Sandy; Draper, John; Elsom, Rachel; Kirkpatrick, Verity; Mathers, John C.; Seal, Chris; Beckmann, Manfred; Haldar, Sumanto; Beattie, John H.; Lodge, John K.; Jenab, Mazda; Keun, Hector; Scalbert, Augustin (2011-01-21)
    The present report summarises a workshop convened by the UK Food Standards Agency (Agency) on 25 March 2010 to discuss the current Agency's funded research on the use of metabolomics technologies in human nutrition research. ...