Browsing IBERS Research papers by Author "Hoffmann, Karl F."

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  • Fitzpatrick, Jennifer M.; Hoffmann, Karl F. (Springer Nature, 2005)
    The end of the 20th century and the start of the new millennium have bore witness to a remarkable revolution in the way parasite/host biological interactions can be conceptually designed and experimentally studied. Although ...
  • Lockyer, Anne E.; Spinks, Jenny; Kane, Richard A.; Hoffmann, Karl F.; Fitzpatrick, Jennifer M.; Rollinson, David; Noble, Leslie R.; Jones, Catherine S. (2008-12-29)
    Background: Biomphalaria glabrata is an intermediate snail host for Schistosoma mansoni, one of the important schistosomes infecting man. B. glabrata/S. mansoni provides a useful model system for investigating the intimate ...
  • Peak, Emily; Chalmers, Iain W.; Hoffmann, Karl F. (PLOS, 2010)
    Background: Schistosomiasis, caused by infection with the blood fluke Schistosoma, is responsible for greater than 200,000 human deaths per annum. Objective high-throughput screens for detecting novel anti-schistosomal ...
  • Peak, Emily; Chalmers, Iain W.; Hoffmann, Karl F. (2010-07-27)
    Background Schistosomiasis, caused by infection with the blood fluke Schistosoma, is responsible for greater than 200,000 human deaths per annum. Objective high-throughput screens for detecting novel anti-schistosomal ...
  • Hoffmann, Karl F.; McCarty, Thomas C.; Segal, David H.; Chiaramonte, Monica; Hesse, Matthias; Davis, Eric M.; Cheever, Allen W.; et al. (FASEB, 2001-09-17)
    Development of polarized immune responses controls resistance and susceptibility to many microorganisms. However, studies of several infectious, allergic, and autoimmune diseases have shown that chronic type-1 and type-2 ...
  • Wynn, Thomas A.; Aliberti, Julio; Hoffmann, Karl F.; Jankovic, Dragana; Feng, Carl G.; Kullberg, Marika C.; Sher, Alan (Taylor & Francis, 2006-01-26)
    his review focuses on the regulatory functions of IL-10 in the response to parasitic and bacterial infection revealed through knockout, cytokine/receptor blocking, and transgenic mouse studies. The various mechanisms that ...
  • Hoffmann, Karl F.; Fitzpatrick, Jennifer M. (Springer Nature, 2004-05-17)
    DNA microarray platforms represent a functional genomics technology that uses structured information obtained from genomic sequencing efforts as a means to study transcriptional processes in a systematic and high-throughput ...
  • Fitzsimmons, C. M.; Stewart, T. J.; Hoffmann, Karl F.; Grogan, Jane L.; Yazdanbakhsh, Maria; Dunne, David W. (2004-08)
    In Schistosoma mansoni and S. japonicum infection, the 22.6 kDa tegumental antigens Sm22.6 and Sj22.6 are principal targets for the human IgE response, and levels of IgE to Sm22.6 have been correlated with resistance to ...
  • Fitzpatrick, Jennifer M.; Johnston, David A.; Williams, Gary W.; Williams, Debbie J.; Freeman, Tom C.; Dunne, David W.; Hoffmann, Karl F. (2005-05-01)
    Global profiling transcriptomes of parasitic helminths offers the potential to simultaneously identify co-ordinately expressed genes, novel genetic programs and uniquely utilized metabolic pathways, which together provide ...
  • Park, Matthew K.; Hoffmann, Karl F.; Cheever, A. W.; Amichay, D.; Wynn, T. A.; Farber, J. M. (2001-11)
    To explore the roles of chemokines in type 1 and type 2 responses in vivo, we examined mRNA expression for a panel of up to 17 chemokines in experimental mouse models using Schistosoma mansoni. These studies revealed that ...
  • Fitzpatrick, Jennifer M.; Fuentes, Jose M.; Chalmers, Iain W.; Wynn, Thomas A.; Modolell, Manuel; Hoffmann, Karl F.; Hesse, Matthias (2009-02)
    Schistosome helminths constitute a major health risk for the human population in many tropical areas. We demonstrate for the first time that several developmental stages of the human parasite Schistosoma mansoni express ...
  • Grevelding, Christoph G.; Hoffmann, Karl F. (2007-11)
    Recent years have seen a revolutionary change in the study of parasitic organisms. Catalysed by the improvements of gene technology and biochemical analyses, comprehensive molecular and cellular information has been generated ...
  • Fitzpatrick, Jennifer M.; Protasio, Anna V.; McArdle, Andrew J.; Williams, Gary A.; Johnston, David A.; Hoffmann, Karl F. (2008-10-22)
    Background: The use of DNA microarray technology to study global Schistosoma gene expression has led to the rapid identification of novel biological processes, pathways or associations. Implementation of standardized DNA ...
  • Adema, Coen M.; Hillier, Ladeana W.; Jones, Catherine S.; Loker, Eric S.; Knight, Matty; Minx, Patrick; Oliveira, Guilherme; Raghavan, Nithya; Shedlock, Andrew; do Amaral, Laurence Rodrigues; Arican-Goktas, Halime D.; Assis, Juliana G.; Baba, Elio Hideo; Baron, Olga L.; Bayne, Christopher J.; Bickham-Wright, Utibe; Biggar, Kyle K.; Blouin, Michael; Bonning, Bryony C.; Botka, Chris; Bridger, Joanna M.; Buckley, Katherine M.; Buddenborg, Sarah K.; Lima Caldeira, Roberta; Carleton, Julia; Carvalho, Omar S.; Castillo, Maria G.; Chalmers, Iain W.; Christensens, Mikkel; Clifton, Sandra; Cosseau, Celine; Coustau, Christine; Cripps, Richard M.; Cuesta-Astroz, Yesid; Cummins, Scott F.; Di Stephano, Leon; Dinguirard, Nathalie; Duval, David; Emrich, Scott; Feschotte, Cédric; Feyereisen, Rene; Fitzgerald, Peter; Fronick, Catrina; Fulton, Lucinda; Galinier, Richard; Gava, Sandra G.; Geusz, Michael; Geyer, Kathrin K.; Giraldo-Calderón, Gloria I.; de Souza Gomes, Matheus; Gordy, Michelle A.; Gourbal, Benjamin; Grunau, Christoph; Hanington, Patrick C.; Hoffmann, Karl F.; Hughes, Daniel; Humphries, Judith; Jackson, Daniel J.; Jannotti-Passos, Liana K.; De Jesus Jeremias, Wander; Jobling, Susan; Kamel, Bishoy; Kapusta, Aurélie; Kaur, Satwant; Koene, Joris M.; Kohn, Andrea B.; Lawson, Dan; Lawton, Scott P; Liang, Di; Limpanont, Yanin; Liu, Sijun; Lockyer, Anne E.; Lovato, Tyanna L.; Ludolf, Fernanda; Magrini, Vince; Mcmanus, Donald P.; Medina, Monica; Misra, Milind; Mitta, Guillaume; Mkoji, Gerald M.; Montague, Michael J.; Montelongo, Cesar; Moroz, Leonid L.; Munoz-Torres, Monica C.; Niazi, Umar; Noble, Leslie R.; Oliveira, Francislon S.; Pais, Fabiano S.; Papenfuss, Anthony T.; Peace, Rob; Pena, Janeth J.; Pila, Emmanuel A.; Quelais, Titouan; Raney, Brian J.; Rast, Jonathan P.; Rollinson, David; Rosse, Izinara C.; Rotgans, Bronwyn; Routledge, Edwin J.; Ryan, Kathryn M.; Scholte, Larissa L. S.; Storey, Kenneth B.; Swain, Martin; Tennessen, Jacob A.; Tomlinson, Chad; Trujillo, Damian L.; Volpi, Emanuela V.; Walker, Anthony J.; Wang, Tianfang; Wannaporn, Ittiprasert; Warren, Wesley C.; Wu, Xiao-Jun; Yoshino, Timothy P.; Yusuf, Mohammed; Zhang, Si-Ming; Zhao, Min; Wilson, Richard K. (2017-05-16)
    Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now ...

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