Browsing IBERS Research papers by Author "Nash, Robert J."

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  • Best, Daniel; Jenkinson, Sarah F.; Thompson, Amber L.; Watkin, David J.; Wilson, Francis X.; Nash, Robert J.; Fleet, George W. J. (2009-09-09)
    The crystal structure of the title compound, C(6)H(11)NO(5), establishes the relative configuration at the four stereogenic centres; the absolute configuration is determined by the use of D-glucuronolactone as the starting ...
  • Kato, Atsushi; Kobayashi, Kaori; Narukawa, Kayo; Minoshima, Yuka; Adachi, Isao; Hirono, Shuichi; Nash, Robert J. (2010-10-01)
    We report the structure–activity relationship of a series of coumarins as aldose reductase 2 (ALR2) inhibitors and their suppressive effect on the accumulation of galactitol in the rat lens. We evaluated their ALR2 selectivity ...
  • Sharp, Hazel J.; Bartholomew, Barbara; Bright, Colin; Latif, Zahid; Sarker, Satyajit D.; Nash, Robert J. (2001-01)
  • Stochmal, Anna; Simonet, Ana M.; Macias, Francisco A.; Oliveira, Maria A.; Abreu, Josi M.; Nash, Robert J.; Oleszek, Wieslaw (2001-08)
    Three flavones, including 4′-O-[2′-O-E-feruloyl-O-β- -glucuronopyranosyl(1→2)-O-β- -glucuronopyranoside]apigenin, 7-O-β- -glucuronopyranosyl-4′-O-[2′-O-E-feruloyl-O-β- -glucuronopyranosyl(1→2)-O-β- -glucuronopyranoside]apigenin ...
  • Haraguchi, Mitsue; Gorniak, Silvana L.; Ikeda, Kyoko; Minami, Yasuhiro; Kato, Atsushi; Watson, Alison A.; Nash, Robert J.; Molyneux, Russell J.; Asano, Naoki (2003-07-11)
    Natural intoxication of livestock by the ingestion of Ipomoea carnea (Convolvulaceae) sometimes occurs in tropical regions of the world. Polyhydroxylated alkaloids were isolated from the leaves, flowers, and seeds of the ...
  • Sarker, Satyajit D.; Latif, Zahid; Nash, Robert J. (2001)
    Nuclear Overhauser effect (nOe) enhancement plays a vital role in structure determination, especially conformational analysis, by NMR (Neuhaus and Williamson, 1989). A number of one- and two-dimensional NMR methods, notably, ...
  • Kato, Atsushi; Kano, Erika; Adachi, Isao; Molyneux, Russell J.; Watson, Alison A.; Nash, Robert J.; Fleet, George W. J.; Wormald, Mark R.; Kizu, Haruhisa; Ikeda, Kyoko; Asano, Naoki (2003-02-07)
    The first polyhydroxylated pyrrolizidine alkaloid with a hydroxymethyl group at C-3 was isolated from pods of Alexa leiopetala (Leguminosae) and designated alexine 1. The Australian legume Castanospermum australe is also ...
  • Stegelmeier, B. L.; Molyneux, R. J.; Nash, Robert J.; Asano, M.; Watson, Alison A. (2008)
    To study various polyhydroxy-alkaloid glycosidase inhibitors, 16 groups of 3 mice were dosed using osmotic minipumps with swainsonine (0, 0.1, 1, and 10 mg/kg/day), castanospermine, and calystegines A3, B2, and C1 (1, 10, ...
  • Asano, Naoki; Yokoyama, Kae; Sakurai, Mio; Ikeda, Kyoko; Kizu, Haruhisa; Kato, Atsushi; Arisawa, Munehisa; Hoke, Dirk; Watson, Alison A.; Nash, Robert J. (2001-07)
    Three dihydroxynortropanes, 2α,7β-dihydroxynortropane, 2α,3β-dihydroxynortropane, and 3α,7β-dihydroxynortropane, were isolated from calystegine-producing plants in the families Convolvulaceae and Solanaceae. 2α,7β-Dihydr ...
  • Sharp, Hazel J.; Latif, Zahid; Bartholomew, Barbara; Thomas, David; Thomas, Bob; Sarker, Satyajit D.; Nash, Robert J. (2001-01)
    Rhamnus pubescens Sibth. & Sm. non Poir., originally from Greece, is a European species of Rhamnaceae (PANDORA Taxonomic Database System, 1999. Flora Europaea. Royal Botanic Garden Edinburgh, UK. Available on line at: ...
  • Hol, W. H. Gera; Nash, Robert J.; Cook, Roger (2005)
  • Kato, Atsushi; Kato, Noriko; Miyauchi, Saori; Minoshima, Yuka; Adachi, Isao; Ikeda, Kyoko; Asano, Naoki; Watson, Alison A.; Nash, Robert J. (2008-03)
    Chromatographic separation of the 50% aqueous EtOH extract of the leaves of the African medicinal tree Baphia nitida resulted in isolation of 10 iminosugars. The plant contained 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine ...
  • Kato, Atsushi; Yasuko, H.; Goto, H.; Hollinshead, Jackie; Nash, Robert J.; Adachi, Isao (2009-03-01)
    Aldose reductase inhibitors have considerable potential for the treatment of diabetic complications, without increased risk of hypoglycemia. Search for components inhibiting aldose reductase led to the discovery of active ...
  • Kato, Atsushi; Nash, Robert J.; Asano, Naoki; Okamoto, T.; Kizu, Haruhisa; Higuchi, Y.; Adachi, Isao; Goto, H.; Hollinshead, Jackie (2006-08-05)
    Ginger (Zingiber officinale Roscoe) continues to be used as an important cooking spice and herbal medicine around the world. Scientific research has gradually verified the antidiabetic effects of ginger. Especially gingerols, ...
  • Dennis, Mark; Hall, Louise M.; Murphy, Patrick J.; Thornhill, Andrew J.; Nash, Robert J.; Winters, Ana L.; Hursthouse, Michael B.; Light, Mark E.; Horton, Peter (2003-04-07)
    The synthesis of a range of cyclic guanidines via intramolecular ring opening of epoxides or iodocyclisation is reported. A preliminary investigation of the glycosidase inhibitory activity of these substances is also ...
  • Al-Shuhaib, Zainab; Böckemeier, Henning; Coghlan, Lawrence; Dörksen, Elina; Jones, Iestyn V.; Murphy, Patrick J.; Nash, Robert J.; Page, James M. (2013-12-04)
    The Pd-mediated π-allyl cyclisation of bis-Cbz- and bis-Boc-protected guanidines 4 and 14b led to the formation of five- and six-membered heterocycles 5 and 17 in high yields.
  • Jones, Laurence; Hollinshead, Jackie; Fleet, George W. J.; Thompson, Amber L.; Watkin, David J.; Gal, Zoltan A.; Jenkinson, Sarah F.; Kato, Atsushi; Nash, Robert J. (2010-09)
    The Australian leguminous tree Castanospermum australe contains the anti-viral glucose analogue indolizidine alkaloid castanospermine. As the result of a search for new bioactive carbohydrate-like compounds we now report ...
  • Ameijde, Jeroen V.; Horne, Graeme; Wormald, Mark R.; Dwek, Raymond A.; Nash, Robert J.; Wyn-Jones, David Paul; Evinson, Emma L.; Fleet, George W. J. (2006-10-16)
    3-epi-Casuarine, the first naturally occurring stereoisomer of casuarine, was isolated from Myrtus communis L. The glycosidase inhibition profile and NMR spectra of 3-epi-casuarine are compared with those of casuarine; the ...
  • Cowan, Sally; Bartholomew, Barbara; Watson, Alison A.; Bright, Colin; Latif, Zahid; Sarker, Satyajit D.; Nash, Robert J. (2001-01)
    Cupressus lusitanica Mill. (Family: Cupressaceae), commonly known as ‘Mexican cypress’ or ‘Cedar-of-Goa', is an ornamental plant found extensively in Mexico, El Salvador, Guatemala and Honduras, and also in other parts of ...
  • Cowan, S.; Stewart, M.; Abbiw, D. K.; Latif, Zahid; Sarker, S. D.; Nash, Robert J. (2001-01)
    Three lignans, pinoresinol 1., 8-hydroxypinoresinol 2. and olivil 3. have been isolated from the leaves of Strophanthus gratus by reversed-phase HPLC.

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