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Browsing IBERS Research papers by Author "O'Neill, Sandra M."

Now showing items 1-6 of 6

The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function

Hamilton, Clare M.; Dowling, David J.; Loscher, Christine E.; Morphew, Russell M.; Brophy, Peter M.; O'Neill, Sandra M. (2009-06-01)

Parasitic worms and molecules derived from them have powerful anti-inflammatory properties and are shown to have therapeutic effects on inflammatory diseases. The helminth Fasciola hepatica has been reported to suppress ...
The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function.

Hamilton, Clare M.; Dowling, David; Loscher, Christine E.; Morphew, Russell M.; Brophy, Peter M.; O'Neill, Sandra M. (2009-06-01)

Parasitic worms and molecules derived from them have powerful anti-inflammatory properties and are shown to have therapeutic effects on inflammatory diseases. The helminth Fasciola hepatica has been reported to suppress ...
Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica resleased by Nonident P40

Morphew, R. M.; Hamilton, Clare M.; Wright, H. A.; Dowling, David J.; O'Neill, Sandra M.; Brophy, P. M. (2012-09-11)

Fasciola hepatica NP-40 released protein extract (FhNPE) exhibits potent Th1 immunosuppressive properties in vitro and in vivo. However, the protein composition of this active fraction, responsible for Th1 immune modulatory ...
Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses

Dowling, David J.; Hamilton, Clare M.; Donnelly, Sheila; James, E. La Course J.; Brophy, Peter M.; Dalton, John; O'Neill, Sandra M. (2010-02)

Fasciola hepatica is a helminth pathogen that drives Th2/Treg immune responses in its mammalian host. The parasite releases a large number of molecules that are critical to inducing this type of immune response. Here we ...
Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses

Dowling, David J.; Hamilton, Clare M.; Donnelly, Stephen; James, E. La Course J.; Brophy, Peter M.; Dalton, John; O'Neill, Sandra M. (2010-02-01)

Fasciola hepatica is a helminth pathogen that drives Th2/Treg immune responses in its mammalian host. The parasite releases a large number of molecules that are critical to inducing this type of immune response. Here we ...
The Sigma Class glutathione transferase from the liver fluke Fasciola hepatica

LaCourse, E. James; Perally, S.; Morphew, R. M.; Moxon, J. V.; Prescott, Mark C.; Dowling, David J.; O'Neill, Sandra M.; Kipar, Anja; Hetzel, Udo; Hoey, Elizabeth; Zafra, Rafael; Buffoni, Leandro; Arévalo, José Pérez; Brophy, P. M. (2012-05-01)

Background: Liver fluke infection of livestock causes economic losses of over US$ 3 billion worldwide per annum. The disease is increasing in livestock worldwide and is a re-emerging human disease. There are currently no ...

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