Show simple item record Gatherer, Derek McEwan, Neil R. 2008-12-04T15:58:23Z 2008-12-04T15:58:23Z 2003-08
dc.identifier.citation Gatherer , D & McEwan , N R 2003 , ' Analysis of Sequence Periodicity in E. coli Proteins: Empirical Investigation of the “Duplication and Divergence” Theory of Protein Evolution ' Journal of Molecular Evolution , vol 57 , no. 2 , pp. 149-158 . DOI: 10.1007/s00239-002-2462-1 en
dc.identifier.issn 0022-2844
dc.identifier.other PURE: 91177
dc.identifier.other PURE UUID: dc0ea8f3-cbfe-49d4-baa7-1eaa55505cb2
dc.identifier.other dspace: 2160/1371
dc.identifier.other DSpace_20121128.csv: row: 1201
dc.identifier.other Scopus: 0042887052
dc.identifier.uri en
dc.description Gatherer, D., and McEwan, N.R. (2003). Analysis of sequence periodicity in E. coli proteins: empirical investigation of the 'duplication and divergence' theory of protein evolution. Journal of Molecular Evolution 57, 149-158. RAE2008 en
dc.description.abstract Periodicity was quantified in 4289 Escherichia coli K12 confirmed and putative protein sequences, using a simple chi-square technique previously shown to reveal triplet period periodicity in coding DNA. Periodicities were calculated from period n = 2 to period n = 50 in nine different alphabetic representations of the proteins. By comparison with a randomly generated proteome of the same compositional content, the E. coli proteome does not contain a significant excess of periodic proteins. However, 60 proteins do appear to be significantly periodic in at least one alphabetic representation, after Bonferroni correction, at p <0.01, and 30 at p <0.001. These are compared with significantly periodic proteins of solved three-dimensional structure, detected by an identical analysis of the sequences from a protein structure database. It is concluded that there is no evidence for the presence of a proteome-wide quasi-periodicity as predicted by the duplication and divergence model of protein evolution and that the major periodicity detected is a consequence of the repetitive tendencies within -helices. However, it is not possible to explain all sequence periodicities in terms of observable secondary structure, as in cases where sequence periodicity can be compared to solved structure, there is often no structural regularity that would provide an obvious explanation in terms of natural selection on protein function. en
dc.format.extent 10 en
dc.language.iso eng
dc.relation.ispartof Journal of Molecular Evolution en
dc.rights en
dc.subject periodicity en
dc.subject proteome en
dc.subject E. coli en
dc.subject gene duplication en
dc.title Analysis of Sequence Periodicity in E. coli Proteins: Empirical Investigation of the “Duplication and Divergence” Theory of Protein Evolution en
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en

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