Analysis of Sequence Periodicity in E. coli Proteins: Empirical Investigation of the “Duplication and Divergence” Theory of Protein Evolution

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dc.contributor.author McEwan, Neil R.
dc.contributor.author Gatherer, Derek
dc.date.accessioned 2008-12-04T15:58:23Z
dc.date.available 2008-12-04T15:58:23Z
dc.date.issued 2003-08
dc.identifier.citation McEwan , N R & Gatherer , D 2003 , ' Analysis of Sequence Periodicity in E. coli Proteins: Empirical Investigation of the “Duplication and Divergence” Theory of Protein Evolution ' Journal of Molecular Evolution , vol 57 , no. 2 , pp. 149-158 . en
dc.identifier.issn 0022-2844
dc.identifier.other PURE: 91177
dc.identifier.other dspace: 2160/1371
dc.identifier.uri http://hdl.handle.net/2160/1371
dc.identifier.uri http://www.springerlink.com/content/5k93ftdltdxgq6e6/ en
dc.description Gatherer, D., and McEwan, N.R. (2003). Analysis of sequence periodicity in E. coli proteins: empirical investigation of the 'duplication and divergence' theory of protein evolution. Journal of Molecular Evolution 57, 149-158. RAE2008 en
dc.description.abstract Periodicity was quantified in 4289 Escherichia coli K12 confirmed and putative protein sequences, using a simple chi-square technique previously shown to reveal triplet period periodicity in coding DNA. Periodicities were calculated from period n = 2 to period n = 50 in nine different alphabetic representations of the proteins. By comparison with a randomly generated proteome of the same compositional content, the E. coli proteome does not contain a significant excess of periodic proteins. However, 60 proteins do appear to be significantly periodic in at least one alphabetic representation, after Bonferroni correction, at p <0.01, and 30 at p <0.001. These are compared with significantly periodic proteins of solved three-dimensional structure, detected by an identical analysis of the sequences from a protein structure database. It is concluded that there is no evidence for the presence of a proteome-wide quasi-periodicity as predicted by the duplication and divergence model of protein evolution and that the major periodicity detected is a consequence of the repetitive tendencies within -helices. However, it is not possible to explain all sequence periodicities in terms of observable secondary structure, as in cases where sequence periodicity can be compared to solved structure, there is often no structural regularity that would provide an obvious explanation in terms of natural selection on protein function. en
dc.format.extent 10 en
dc.language.iso eng
dc.relation.ispartof Journal of Molecular Evolution en
dc.title Analysis of Sequence Periodicity in E. coli Proteins: Empirical Investigation of the “Duplication and Divergence” Theory of Protein Evolution en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1007/s00239-002-2462-1
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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