Evolution of prokaryotic two-component system signaling pathways: Gene fusions and fissions

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dc.contributor.author Cock, Peter J. A.
dc.contributor.author Whitworth, David E.
dc.date.accessioned 2008-12-08T12:11:51Z
dc.date.available 2008-12-08T12:11:51Z
dc.date.issued 2008-12-08
dc.identifier.citation Cock , P J A & Whitworth , D E 2008 , Evolution of prokaryotic two-component system signaling pathways: Gene fusions and fissions . Oxford Journals . en
dc.identifier.isbn 1537-1719
dc.identifier.other PURE: 99317
dc.identifier.other dspace: 2160/1436
dc.identifier.uri http://hdl.handle.net/2160/1436
dc.identifier.uri http://mbe.oxfordjournals.org/cgi/reprint/24/11/2355 en
dc.description Peter J. A. Cock and David E. Whitworth (2007) Evolution of Prokaryotic Two-Component System Signaling Pathways: Gene Fusions and Fissions. Molecular Biology and Evolution, 24 (11) 2355-2357. en
dc.description.abstract Two-component systems (TCSs) are common signal transduction systems, typically comprising paired histidine protein kinase (HK) and response regulator (RR) proteins. In many examples, it appears RR and HK genes have fused, producing a 'hybrid kinase ' We have characterized a set of prokaryotic genes encoding RRs, HKs, and hybrid kinases, enabling characterization of gene fusion and fission. Primary factors correlating with fusion rates are the presence of transmembrane helices in HKs and the presence of DNA-binding domains in RRs, features that require correct (and separate) spatial location. In the absence of such features, there is a relative abundance of fused genes. The order of paired HK and RR genes and the nucleotide distance between encoded domains also correlate with apparent gene fusion rates. We propose that localization requirements and relative positioning of encoded domains within TCS genes affect the function (and therefore retention) of hybrid kinases resulting from gene fusion. en
dc.format.extent 3 en
dc.language.iso eng
dc.publisher Oxford Journals
dc.title Evolution of prokaryotic two-component system signaling pathways: Gene fusions and fissions en
dc.type Text en
dc.type.publicationtype Report (commissioned) en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en


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