Show simple item record

dc.contributor.author Brun, Reto
dc.contributor.author Vovelle, Françoise
dc.contributor.author Hamilton, Joanne V.
dc.contributor.author Lehane, Michael J.
dc.contributor.author Munks, Rebecca J. L.
dc.contributor.author Bulet, Philippe
dc.contributor.author Boulanger, Nathalie
dc.date.accessioned 2008-12-12T11:01:28Z
dc.date.available 2008-12-12T11:01:28Z
dc.date.issued 2008-12-12
dc.identifier.citation Brun , R , Vovelle , F , Hamilton , J V , Lehane , M J , Munks , R J L , Bulet , P & Boulanger , N 2008 , ' Epithelial innate immunity - A novel antimicrobial peptide with antiparasitic activity in the blood-sucking insect Stomoxys calcitrans ' Journal of Biological Chemistry , pp. 49921-49926 . en
dc.identifier.other PURE: 101405
dc.identifier.other dspace: 2160/1567
dc.identifier.uri http://hdl.handle.net/2160/1567
dc.identifier.uri http://www.jbc.org/cgi/content/abstract/277/51/49921 en
dc.description Nathalie Boulanger, Rebecca J. L. Munks, Joanne V. Hamilton, Françoise Vovelle, Reto Brun, Mike J. Lehane, and Philippe Bulet (2002). Epithelial innate immunity - A novel antimicrobial peptide with antiparasitic activity in the blood-sucking insect Stomoxys calcitrans. Journal of Biological Chemistry, 277(51), 49921-49926. en
dc.description.abstract The gut epithelium is an essential interface in insects that transmit parasites. We investigated the role that local innate immunity might have on vector competence, taking Stomoxys calcitrans as a model. S. calcitrans is sympatric with tsetse flies, feeds on many of the same vertebrate hosts, and is thus regularly exposed to the trypanosomes that cause African sleeping sickness and nagana. Despite this, S. calcitrans is not a cyclical vector of these trypanosomes. Trypanosomes develop exclusively in the lumen of digestive organs, and so epithelial immune mechanisms, and in particular antimicrobial peptides (AMPs), may be the prime determinants of the fate of an infection. To investigate why S. calcitrans is not a cyclical vector of trypanosomes, we have looked in its midgut for AMPs with trypanolytic activity. We have identified a new AMP of 42 amino acids, which we named stomoxyn, constitutively expressed and secreted exclusively in the anterior midgut of S. calcitrans. It displays an amphipathic helical structure and exhibits a broad activity spectrum affecting the growth of microorganisms. Interestingly, this AMP exhibits trypanolytic activity to Trypanosoma brucei rhodesiense. We argue that stomoxyn may help to explain why S. calcitrans is not a vector of trypanosomes causing African sleeping sickness and nagana. en
dc.format.extent 6 en
dc.language.iso eng
dc.relation.ispartof Journal of Biological Chemistry en
dc.title Epithelial innate immunity - A novel antimicrobial peptide with antiparasitic activity in the blood-sucking insect Stomoxys calcitrans en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Cadair


Advanced Search

Browse

Statistics