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dc.contributor.author Hoffmann, Karl F.
dc.contributor.author McCarty, Thomas C.
dc.contributor.author Segal, David H.
dc.contributor.author Chiaramonte, Monica
dc.contributor.author Hesse, Matthias
dc.contributor.author Davis, Eric M.
dc.contributor.author Cheever, Allen W.
dc.contributor.author et al.
dc.date.accessioned 2008-12-12T11:05:40Z
dc.date.available 2008-12-12T11:05:40Z
dc.date.issued 2001-09-17
dc.identifier.citation Karl F. Hoffmann, Thomas C. McCarty, David H. Segal, Monica Chiaramonte, Matthias Hesse, Eric M. Davis, Allen W. Cheever, Paul S. Meltzer, Herbert C. Morse III, and Thomas A. Wynn (2001). Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type-1 and type-2 cytokine-mediated inflammatory reactions. FASEB 15(13), 2545-2547. en
dc.identifier.isbn 1530-6860 en_US
dc.identifier.uri http://hdl.handle.net/2160/1568
dc.description.abstract Development of polarized immune responses controls resistance and susceptibility to many microorganisms. However, studies of several infectious, allergic, and autoimmune diseases have shown that chronic type-1 and type-2 cytokine responses can also cause significant morbidity and mortality if left unchecked. We used mouse cDNA microarrays to molecularly phenotype the gene expression patterns that characterize two disparate but equally lethal forms of liver pathology that develop in Schistosoma mansoni infected mice polarized for type-1 and type-2 cytokine responses. Hierarchical clustering analysis identified at least three groups of genes associated with a polarized type-2 response and two linked with an extreme type-1 cytokine phenotype. Predictions about liver fibrosis, apoptosis, and granulocyte recruitment and activation generated by the microarray studies were confirmed later by traditional biological assays. The data show that cDNA microarrays are useful not only for determining coordinated gene expression profiles but are also highly effective for molecularly "fingerprinting" diseased tissues. Moreover, they illustrate the potential of genome-wide approaches for generating comprehensive views on the molecular and biochemical mechanisms regulating infectious disease pathogenesis. en
dc.language.iso en en
dc.publisher FASEB en
dc.relation.ispartof RAE2008 en_US
dc.relation.isreferencedby http://dx.doi.org/10.1096/fj.01-0306fje en
dc.title Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type-1 and type-2 cytokine-mediated inflammatory reactions en
dc.type Text en
dc.type.publicationtype refereed published journal paper en
dc.identifier.doi http://www.fasebj.org/cgi/content/full/15/13/2545
dc.identifier.duplicate True


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