Show simple item record Timothy G. en_US Hanan H. en_US Michael J. en_US Aaron G. en_US Teresa M. en_US Tim A. en_US Martha J. en_US Judith E. en_US 2008-12-15T09:44:56Z 2008-12-15T09:44:56Z 2006-12-01 en_US
dc.identifier en_US
dc.identifier.citation Geary , T G , Omar , H H , Kimber , M J , Maule , A G , Kubiak , T M , Day , T A , Larsen , M J & Humphries , J E 2006 , ' Identification of a platyhelminth neuropeptide receptor ' International Journal for Parasitology , pp. 725-733 . , 10.1016/j.ijpara.2006.12.019 en_US
dc.identifier.other PURE: 93017 en_US
dc.identifier.other dspace: 2160/1604 en_US
dc.description.abstract We report the characterisation of the first neuropeptide receptor from the phylum Platyhelminthes, an early-diverging phylum which includes a number of important human and veterinary parasites. The G protein-coupled receptor (GPCR) was identified from the model flatworm Girardia tigrina (Tricladida: Dugesiidae) based on the presence of motifs widely conserved amongst GPCRs. In two different assays utilising heterologous expression in Chinese hamster ovary cells, the Girardia GPCR was most potently activated by neuropeptides from the FMRFamide-like peptide class. The most potent platyhelminth neuropeptide in both assays was GYIRFamide, a FMRFamide-like peptide known to be present in G. tigrina. There was no activation by neuropeptide Fs, another class of flatworm neuropeptides. Also active were FMRFamide-like peptides derived from other phyla but not known to be present in any platyhelminth. Most potent among these were nematode neuropeptides encoded by the Caenorhabditis elegans flp-1 gene which share a PNFLRFamide carboxy terminal motif. The ability of nematode peptides to stimulate a platyhelminth receptor demonstrates a degree of structural conservation between FMRFamide-like peptide receptors from these two distinct, distant phyla which contain parasitic worms. en_US
dc.format.extent 9 en_US
dc.relation.ispartof International Journal for Parasitology en_US
dc.title Identification of a platyhelminth neuropeptide receptor en_US
dc.contributor.pbl Aberystwyth University en_US
dc.contributor.pbl Institute of Biological, Environmental and Rural Sciences en_US

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