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dc.contributor.author Geary, Timothy G.
dc.contributor.author Omar, Hanan H.
dc.contributor.author Kimber, Michael J.
dc.contributor.author Maule, Aaron G.
dc.contributor.author Kubiak, Teresa M.
dc.contributor.author Day, Tim A.
dc.contributor.author Larsen, Martha J.
dc.contributor.author Humphries, Judith E.
dc.date.accessioned 2008-12-15T09:44:56Z
dc.date.available 2008-12-15T09:44:56Z
dc.date.issued 2006-12-01
dc.identifier.citation Geary , T G , Omar , H H , Kimber , M J , Maule , A G , Kubiak , T M , Day , T A , Larsen , M J & Humphries , J E 2006 , ' Identification of a platyhelminth neuropeptide receptor ' International Journal for Parasitology , pp. 725-733 . , 10.1016/j.ijpara.2006.12.019 en
dc.identifier.other PURE: 93017
dc.identifier.other dspace: 2160/1604
dc.identifier.uri http://hdl.handle.net/2160/1604
dc.description Hanan H. Omar, Judith E.Humphries, Martha J. Larsen, Teresa M. Kubiak, Timothy G. Geary, Aaron G. Maule, Michael J. Kimber and Tim A. Day (2006). Identification of a platyhelminth neuropeptide receptor. International Journal for Parasitology, 37 (7), 725-733. Sponsorship: National Institutes of Health Grant R01-AI49162 RAE2008 en
dc.description.abstract We report the characterisation of the first neuropeptide receptor from the phylum Platyhelminthes, an early-diverging phylum which includes a number of important human and veterinary parasites. The G protein-coupled receptor (GPCR) was identified from the model flatworm Girardia tigrina (Tricladida: Dugesiidae) based on the presence of motifs widely conserved amongst GPCRs. In two different assays utilising heterologous expression in Chinese hamster ovary cells, the Girardia GPCR was most potently activated by neuropeptides from the FMRFamide-like peptide class. The most potent platyhelminth neuropeptide in both assays was GYIRFamide, a FMRFamide-like peptide known to be present in G. tigrina. There was no activation by neuropeptide Fs, another class of flatworm neuropeptides. Also active were FMRFamide-like peptides derived from other phyla but not known to be present in any platyhelminth. Most potent among these were nematode neuropeptides encoded by the Caenorhabditis elegans flp-1 gene which share a PNFLRFamide carboxy terminal motif. The ability of nematode peptides to stimulate a platyhelminth receptor demonstrates a degree of structural conservation between FMRFamide-like peptide receptors from these two distinct, distant phyla which contain parasitic worms. en
dc.format.extent 9 en
dc.language.iso eng
dc.relation.ispartof International Journal for Parasitology en
dc.title Identification of a platyhelminth neuropeptide receptor en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1016/j.ijpara.2006.12.019
dc.contributor.institution Aberystwyth University en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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