Plasticity demonstrated in the proteome of a parasitic nematode within the intestine of different host strains

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dc.contributor.author Morgan, Charlie T.
dc.contributor.author Rushbrook, B. J.
dc.contributor.author Bailey, Kevin
dc.contributor.author Greetham, Darren
dc.contributor.author Hamilton, Joanne V.
dc.contributor.author Barrett, John
dc.contributor.author LaCourse, E. James
dc.contributor.author Brophy, Peter M.
dc.date.accessioned 2008-12-15T11:46:29Z
dc.date.available 2008-12-15T11:46:29Z
dc.date.issued 2008-12-15
dc.identifier.citation Morgan , C T , Rushbrook , B J , Bailey , K , Greetham , D , Hamilton , J V , Barrett , J , LaCourse , E J & Brophy , P M 2008 , ' Plasticity demonstrated in the proteome of a parasitic nematode within the intestine of different host strains ' Proteomics , pp. 4633-4645 . en
dc.identifier.other PURE: 101970
dc.identifier.other dspace: 2160/1612
dc.identifier.uri http://hdl.handle.net/2160/1612
dc.identifier.uri http://www3.interscience.wiley.com/cgi-bin/abstract/112728479/ en
dc.description Charly Morgan, Elwyn James LaCourse, Benjamin J. Rushbrook, Darren Greetham, Joanne V. Hamilton, John Barrett, Kevin Bailey, Peter M. Brophy (2006). Plasticity demonstrated in the proteome of a parasitic nematode within the intestine of different host strains. Proteomics, 6(16), 4633-4645. en
dc.description.abstract The soluble global proteome of adult nematode Heligmosomoides polygyrus (H. p.) bakeri, a hookworm laboratory model was compared for the first time in the intestines of a slow-responder mouse host strain (C57/BL10) that is known to support a primary parasite infection for many months, and rapid-responder mouse host (SWR) that is known to eliminate the nematode infection by week 6 postinfection. At week 4 postinfection, major adult nematode proteins selectively produced following establishment of infection in C57/BL10 hosts include several globin forms, calreticulin and a phosphatidylethanolamine-binding protein. The increased synthesis of forms of myosin, actin and troponin in the nematode living in the rapid-responder SWR host may relate to the attempted reorganisation or repair of the cytoskeleton and/or muscle layer in the host immune initiated, increased mucus production and smooth muscle activity within intestinal environment. Initial evidence suggests weakly antigenic forms of globins dominant in the cytosol of H. p. bakeri adults in the intestinal environment compared to their low production in a related free-living nematode. The demonstration of considerable plasticity within a parasitic nematode proteome provides a molecular basis for the previously observed phenotypic plasticity within different host environments. Proteome plasticity has relevance to the efficiency of future vaccine and drug therapy, and the continued failure of defined antigen vaccines in mammalian populations. en
dc.format.extent 13 en
dc.language.iso eng
dc.relation.ispartof Proteomics en
dc.title Plasticity demonstrated in the proteome of a parasitic nematode within the intestine of different host strains en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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