Show simple item record Edwards, Joan E. McEwan, Neil R. Wallace, R. John 2009-05-21T08:08:58Z 2009-05-21T08:08:58Z 2008-06-01
dc.identifier.citation Edwards , J E , McEwan , N R & Wallace , R J 2008 , ' Adaptation to flavomycin in the ruminal bacterium, Prevotella bryantii ' Journal of Applied Microbiology , vol 104 , no. 6 , pp. 1617-1623 . DOI: 10.1111/j.1365-2672.2007.03689.x en
dc.identifier.issn 1365-2672
dc.identifier.other PURE: 101126
dc.identifier.other PURE UUID: 247b6c70-8de5-494c-9952-344de4280255
dc.identifier.other dspace: 2160/2261
dc.identifier.other DSpace_20121128.csv: row: 1637
dc.identifier.other IBERS: 0000017033
dc.identifier.other Ibers_20121112_1204.csv: row: 93
dc.identifier.other RAD: 2893
dc.identifier.other RAD_Outputs_All_ID_Import_20121105.csv: row: 1409
dc.identifier.other Scopus: 44249098281
dc.identifier.other PubMed: 18194251
dc.description Edwards, J. E., McEwan, N. R., Wallace, R. J. (2008). Adaptation to flavomycin in the ruminal bacterium, Prevotella bryantii.  Journal of Applied Microbiology, 104, (6), 1617-1623. On file IMPF: 02.50 RONO: 1920 3008 Sponsorship: SEERAD en
dc.description.abstract Aims: The recent EU ban of growth-promoting antibiotics in animal production was based on fears concerning antibiotic resistance being transmitted to human pathogens. This paper explores the adaptation mechanism of a common ruminal bacterium, Prevotella bryantii, to one of the banned compounds, flavomycin (flavophospholipol). Methods and Results: Growth in the presence of flavomycin (2 and 20 μg ml−1) was characterized by a concentration-dependent increase in the length of the lag phase, which decreased after previous flavomycin exposure. From growth patterns on solid medium, decreased sensitivity appeared to be due to a whole-population adaptation. Proteomic analysis indicated upregulation of three native proteins occurred following flavomycin adaptation. Further analysis of two of these proteins resulted in no database matches, suggesting that they may be species-specific. Flavomycin adaptation also resulted in co-adaptation to bacitracin and vancomycin. Conclusions: Adaptation of P. bryantii to flavomycin, which also resulted in co-adaptation to bacitracin and vancomycin, may involve an increased availability of undecaprenyl pyrophosphate. Significance and Impact of the Study: The use of flavomycin, and similar growth-promoting antibiotics, in animal production may prompt adaptive responses in ruminal bacteria which can significantly change their antibiotic sensitivity. en
dc.format.extent 7 en
dc.language.iso eng
dc.relation.ispartof Journal of Applied Microbiology en
dc.rights en
dc.subject adaptation en
dc.subject antibiotic en
dc.subject flavomycin en
dc.subject Prevotella bryantii en
dc.subject resistance en
dc.subject rumen en
dc.title Adaptation to flavomycin in the ruminal bacterium, Prevotella bryantii en
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en

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