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dc.contributor.author Delneri, Daniela
dc.contributor.author Hoyle, David C.
dc.contributor.author Gkargkas, Konstantinos
dc.contributor.author Cross, Emma J. M.
dc.contributor.author Rash, Bharat
dc.contributor.author Zeef, Leo
dc.contributor.author Leong, Hui-Sun
dc.contributor.author Davey, Hazel M.
dc.contributor.author Hayes, Andrew
dc.contributor.author Kell, Douglas B.
dc.contributor.author Griffith, Gareth W.
dc.contributor.author Oliver, Stephen G.
dc.date.accessioned 2009-05-21T11:01:34Z
dc.date.available 2009-05-21T11:01:34Z
dc.date.issued 2008-01-01
dc.identifier.citation Delneri , D , Hoyle , D C , Gkargkas , K , Cross , E J M , Rash , B , Zeef , L , Leong , H-S , Davey , H M , Hayes , A , Kell , D B , Griffith , G W & Oliver , S G 2008 , ' Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures ' Nature Genetics , vol 40 , no. 1 , pp. 113-117 . , 10.1038/ng.2007.49 en
dc.identifier.issn 1546-1718
dc.identifier.other PURE: 102128
dc.identifier.other dspace: 2160/2298
dc.identifier.uri http://hdl.handle.net/2160/2298
dc.identifier.uri http://www.nature.com/ng/journal/v40/n1/full/ng.2007.49.html en
dc.description IMPF: 30.26 RONO: 00 en
dc.description.abstract Using competition experiments in continuous cultures grown in different nutrient environments (glucose limited, ammonium limited, phosphate limited and white grape juice), we identified genes that show haploinsufficiency phenotypes (reduced growth rate when hemizygous) or haploproficiency phenotypes (increased growth rate when hemizygous). Haploproficient genes (815, 1,194, 733 and 654 in glucose-limited, ammonium-limited, phosphate-limited and white grape juice environments, respectively) frequently show that phenotype in a specific environmental context. For instance, genes encoding components of the ubiquitination pathway or the proteasome show haploproficiency in nitrogen-limited conditions where protein conservation may be beneficial. Haploinsufficiency is more likely to be observed in all environments, as is the case with genes determining polar growth of the cell. Haploproficient genes seem randomly distributed in the genome, whereas haploinsufficient genes (685, 765, 1,277 and 217 in glucose-limited, ammonium-limited, phosphate-limited and white grape juice environments, respectively) are over-represented on chromosome III. This chromosome determines a yeast's mating type, and the concentration of haploinsufficient genes there may be a mechanism to prevent its loss. en
dc.format.extent 5 en
dc.language.iso eng
dc.relation.ispartof Nature Genetics en
dc.title Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1038/ng.2007.49
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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