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dc.contributor.author Daniela en_US
dc.contributor.author David C. en_US
dc.contributor.author Konstantinos en_US
dc.contributor.author Emma J. M. en_US
dc.contributor.author Bharat en_US
dc.contributor.author Leo en_US
dc.contributor.author Hui-Sun en_US
dc.contributor.author Hazel M. en_US
dc.contributor.author Andrew en_US
dc.contributor.author Douglas B. en_US
dc.contributor.author Gareth W. en_US
dc.contributor.author Stephen G. en_US
dc.date.accessioned 2009-05-21T11:01:34Z
dc.date.available 2009-05-21T11:01:34Z
dc.date.issued 2008-01-01 en_US
dc.identifier http://dx.doi.org/10.1038/ng.2007.49 en_US
dc.identifier.citation Delneri , D , Hoyle , D C , Gkargkas , K , Cross , E J M , Rash , B , Zeef , L , Leong , H-S , Davey , H M , Hayes , A , Kell , D B , Griffith , G W & Oliver , S G 2008 , ' Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures ' Nature Genetics , vol 40 , no. 1 , pp. 113-117 . , 10.1038/ng.2007.49 en_US
dc.identifier.other PURE: 102128 en_US
dc.identifier.other dspace: 2160/2298 en_US
dc.identifier.uri http://hdl.handle.net/2160/2298
dc.description.abstract Using competition experiments in continuous cultures grown in different nutrient environments (glucose limited, ammonium limited, phosphate limited and white grape juice), we identified genes that show haploinsufficiency phenotypes (reduced growth rate when hemizygous) or haploproficiency phenotypes (increased growth rate when hemizygous). Haploproficient genes (815, 1,194, 733 and 654 in glucose-limited, ammonium-limited, phosphate-limited and white grape juice environments, respectively) frequently show that phenotype in a specific environmental context. For instance, genes encoding components of the ubiquitination pathway or the proteasome show haploproficiency in nitrogen-limited conditions where protein conservation may be beneficial. Haploinsufficiency is more likely to be observed in all environments, as is the case with genes determining polar growth of the cell. Haploproficient genes seem randomly distributed in the genome, whereas haploinsufficient genes (685, 765, 1,277 and 217 in glucose-limited, ammonium-limited, phosphate-limited and white grape juice environments, respectively) are over-represented on chromosome III. This chromosome determines a yeast's mating type, and the concentration of haploinsufficient genes there may be a mechanism to prevent its loss. en_US
dc.format.extent 5 en_US
dc.relation.ispartof Nature Genetics en_US
dc.title Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures en_US
dc.contributor.pbl Institute of Biological, Environmental and Rural Sciences en_US


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