Show simple item record Y. en_US Atsushi en_US Alison A. en_US J. en_US Isao en_US Robert J. en_US 2009-05-21T12:43:25Z 2009-05-21T12:43:25Z 2008-08-06 en_US
dc.identifier en_US
dc.identifier.citation Minoshima , Y , Kato , A , Watson , A A , Yamamoto , J , Adachi , I & Nash , R J 2008 , ' Protective effect of dietary chamomile tea on diabetic compliances ' Journal of Agricultural and Food Chemistry , vol 56 , no. 17 , pp. 8206-8211 . , 10.1021/jf8014365 en_US
dc.identifier.other PURE: 103038 en_US
dc.identifier.other dspace: 2160/2333 en_US
dc.description.abstract Matricaria chamomilla L., known as “chamomile”, has been used as an herbal tea or supplementary food all over the world. We investigated the effects of chamomile hot water extract and its major components on the prevention of hyperglycemia and the protection or improvement of diabetic complications in diabetes mellitus. Hot water extract, esculetin (3) and quercetin (7) have been found to show moderate inhibition of sucrase with IC50 values of 0.9 mg/mL and 72 and 71 μM, respectively. In a sucrose-loading test, the administration of esculetin (50 mg/kg body weight) fully suppressed hyperglycemia after 15 and 30 min, but the extract (500 mg/kg body weight) and quercetin (50 mg/kg body weight) were less effective. On the other hand, a long-term feed test (21 days) using a streptozotocin-induced rat diabetes model revealed that the same doses of extract and quercetin showed significant suppression of blood glucose levels. It was also found that these samples increased the liver glycogen levels. Moreover, chamomile extract showed potent inhibition against aldose reductase (ALR2), with an IC50 value of 16.9 μg/mL, and its components, umbelliferone (1), esculetin (3), luteolin (6), and quercetin (7), could significantly inhibit the accumulation of sorbitol in human erythrocytes. These results clearly suggested that daily consumption of chamomile tea with meals could contribute to the prevention of the progress of hyperglycemia and diabetic complications. en_US
dc.format.extent 6 en_US
dc.relation.ispartof Journal of Agricultural and Food Chemistry en_US
dc.subject diabetic complications en_US
dc.subject ?-glucosidase en_US
dc.subject aldose reductase en_US
dc.subject hyperglycemia en_US
dc.subject chamomile tea en_US
dc.subject Matricaria chamomilla en_US
dc.title Protective effect of dietary chamomile tea on diabetic compliances en_US
dc.contributor.pbl Aberystwyth University en_US
dc.contributor.pbl Institute of Biological, Environmental and Rural Sciences en_US

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