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dc.contributor.author Minoshima, Y.
dc.contributor.author Kato, Atsushi
dc.contributor.author Watson, Alison A.
dc.contributor.author Yamamoto, J.
dc.contributor.author Adachi, Isao
dc.contributor.author Nash, Robert J.
dc.date.accessioned 2009-05-21T12:43:25Z
dc.date.available 2009-05-21T12:43:25Z
dc.date.issued 2008-08-06
dc.identifier.citation Minoshima , Y , Kato , A , Watson , A A , Yamamoto , J , Adachi , I & Nash , R J 2008 , ' Protective effect of dietary chamomile tea on diabetic compliances ' Journal of Agricultural and Food Chemistry , vol 56 , no. 17 , pp. 8206-8211 . , 10.1021/jf8014365 en
dc.identifier.issn 0021-8561
dc.identifier.other PURE: 103038
dc.identifier.other dspace: 2160/2333
dc.identifier.uri http://hdl.handle.net/2160/2333
dc.identifier.uri http://pubs.acs.org/doi/full/10.1021/jf8014365 en
dc.description Kato, A., Minoshima, Y., Yamamoto, J., Adachi, I., Watson, A. A., Nash, R. J. (2008). Protective effect of dietary chamomile tea on diabetic compliances.  Journal of Agriculture and Food Chemistry, 56, (17), 8206-8211. IMPF: 02.56 en
dc.description.abstract Matricaria chamomilla L., known as “chamomile”, has been used as an herbal tea or supplementary food all over the world. We investigated the effects of chamomile hot water extract and its major components on the prevention of hyperglycemia and the protection or improvement of diabetic complications in diabetes mellitus. Hot water extract, esculetin (3) and quercetin (7) have been found to show moderate inhibition of sucrase with IC50 values of 0.9 mg/mL and 72 and 71 μM, respectively. In a sucrose-loading test, the administration of esculetin (50 mg/kg body weight) fully suppressed hyperglycemia after 15 and 30 min, but the extract (500 mg/kg body weight) and quercetin (50 mg/kg body weight) were less effective. On the other hand, a long-term feed test (21 days) using a streptozotocin-induced rat diabetes model revealed that the same doses of extract and quercetin showed significant suppression of blood glucose levels. It was also found that these samples increased the liver glycogen levels. Moreover, chamomile extract showed potent inhibition against aldose reductase (ALR2), with an IC50 value of 16.9 μg/mL, and its components, umbelliferone (1), esculetin (3), luteolin (6), and quercetin (7), could significantly inhibit the accumulation of sorbitol in human erythrocytes. These results clearly suggested that daily consumption of chamomile tea with meals could contribute to the prevention of the progress of hyperglycemia and diabetic complications. en
dc.format.extent 6 en
dc.language.iso eng
dc.relation.ispartof Journal of Agricultural and Food Chemistry en
dc.subject diabetic complications en
dc.subject ?-glucosidase en
dc.subject aldose reductase en
dc.subject hyperglycemia en
dc.subject chamomile tea en
dc.subject Matricaria chamomilla en
dc.title Protective effect of dietary chamomile tea on diabetic compliances en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1021/jf8014365
dc.contributor.institution Aberystwyth University en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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