Show simple item record Herath, Shan Williams, Erin J. Sheldon, I. Martin Nash, Deborah M. Miller, Aleisha N. A. 2009-05-26T09:14:51Z 2009-05-26T09:14:51Z 2009-05-26
dc.identifier.citation Herath , S , Williams , E J , Sheldon , I M , Nash , D M & Miller , A N A 2009 , ' Uterine diseases in cattle after parturition ' Unknown Journal , pp. 115-121 . en
dc.identifier.other PURE: 113241
dc.identifier.other dspace: 2160/2387
dc.description Sheldon, M., Williams, E. J., Miller, A. N. A., Nash, D. M., Herath, S. (2008). Uterine diseases in cattle after parturition.  The Veterinary Journal, 176, (1), 115-121. en
dc.description.abstract Bacterial contamination of the uterine lumen is common in cattle after parturition, often leading to infection and uterine disease. Clinical disease can be diagnosed and scored by examination of the vaginal mucus, which reflects the presence of pathogenic bacteria such as Escherichia coli and Arcanobacterium pyogenes. Viruses may also cause uterine disease and bovine herpesvirus 4 (BoHV-4) is tropic for endometrial cells, causing a rapid cytopathic effect. The elimination of pathogens by the innate immune system is dependent on pattern recognition receptors binding pathogen-associated molecules. Uterine epithelial and stromal cells express receptors such as Toll-like Receptor 4 that binds E. coli lipopolysaccharide. The infertility associated with uterine disease is caused by damage to the endometrium and disruption of ovarian cyclic activity. Bacteria modulate endometrial prostaglandin secretion, and perturb ovarian follicle growth and function. Understanding the molecular basis of uterine disease will lead to novel approaches to treating infertility. en
dc.format.extent 7 en
dc.language.iso eng
dc.relation.ispartof Unknown Journal en
dc.title Uterine diseases in cattle after parturition en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en

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