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dc.contributor.author Cock, Peter J. A.
dc.contributor.author Whitworth, David E.
dc.date.accessioned 2009-05-26T10:52:37Z
dc.date.available 2009-05-26T10:52:37Z
dc.date.issued 2009-05-26
dc.identifier.citation Cock , P J A & Whitworth , D E 2009 , ' Two-component systems of the myxobacteria: structure, diversity and evolutionary relationships ' Unknown Journal , pp. 360-372 . en
dc.identifier.other PURE: 113802
dc.identifier.other dspace: 2160/2395
dc.identifier.uri http://hdl.handle.net/2160/2395
dc.description Whitworth, D. E., Cock, P. J. A. (2008). Two-component systems of the myxobacteria: structure, diversity and evolutionary relationships.  Microbiology, 154, 360-372. en
dc.description.abstract Two-component systems (TCSs) are a large family of signalling pathways characterized by the successive transfer of phosphoryl groups between the histidine and aspartate residues of paired histidine kinase and response regulator proteins. With the availability of genome sequences for four genera of myxobacteria it has become possible to assess the genomic complements of myxobacterial TCS genes and to characterize features of their organization and evolutionary heritage. In this study we have compiled lists of the TCS genes within myxobacterial genomes and characterized their domain architecture, gene organization and evolutionary relationships. In order to provide an appropriate context for our conclusions, where possible we have compared myxobacterial TCSs with those found in 316 other completely sequenced bacteria. Myxobacteria have the largest number of TCSs of any organisms. An unusually low proportion of TCS genes are paired in myxobacterial genomes, and myxobacterial histidine kinases also seem to sense internal signals to an unusual degree. Phylogenetic evidence has allowed us to suggest homologous relationships of proteins across the myxobacteria, and it appears that myxobacterial TCS evolution has been dominated by duplications, gene rearrangements and changes in sensory domain complements. The systematic classification of the TCS proteins of the myxobacteria presented here should also provide a framework for future experimental studies on two-component regulation in these organisms. en
dc.format.extent 13 en
dc.language.iso eng
dc.relation.ispartof Unknown Journal en
dc.title Two-component systems of the myxobacteria: structure, diversity and evolutionary relationships en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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