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dc.contributor.author Rose, Michael T.
dc.contributor.author al, et
dc.contributor.author Miyazawa, K.
dc.contributor.author Kitazawa, Haruki
dc.contributor.author Tanaka, S.
dc.contributor.author Kanaya, T.
dc.contributor.author Takakura, I.
dc.contributor.author Katamine, Shigeru
dc.contributor.author Watanabe, K.
dc.contributor.author Sakaguchi, S.
dc.contributor.author Ohwada, S.
dc.date.accessioned 2009-07-09T08:55:40Z
dc.date.available 2009-07-09T08:55:40Z
dc.date.issued 2009-07-09
dc.identifier.citation Rose , M T , al , Miyazawa , K , Kitazawa , H , Tanaka , S , Kanaya , T , Takakura , I , Katamine , S , Watanabe , K , Sakaguchi , S & Ohwada , S 2009 , ' Immunohistochemical characterization of cell types expressing the cellular prion protein in the small intestine of cattle and mice ' Histochemistry and Cell Biology , pp. 291-301 . en
dc.identifier.other PURE: 117054
dc.identifier.other dspace: 2160/2591
dc.identifier.uri http://hdl.handle.net/2160/2591
dc.description Miyazawa, K., Kanaya, T., Tanaka, S., Takakura, I., Watanabe, K., Ohwada, S., Kitazawa, H., Rose, M. T., Sakaguchi, S., Katamine, S., Yamaguchi, T., Aso, H. (2007). Immunohistochemical characterization of cell types expressing the cellular prion protein in the small intestine of cattle and mice. Histochemistry and Cell Biology, 127, (3), 291-301. en
dc.description.abstract The gastrointestinal tract is thought to be the main site of entry for the pathological isoform of the prion protein (PrPSc). Prion diseases are believed to result from a conformational change of the cellular prion protein (PrPc) to PrPSc. Therefore, PrPc expression is a prerequisite for the infection and spread of the disease to the central nervous system. However, the distribution of PrPc in the gut is still a matter of controversy. We therefore investigated the localization of PrPc in the bovine and murine small intestine. In cattle, most PrPc positive epithelial cells were detected in the duodenum, while a few positive cells were found in the jejunum. PrPc was expressed in serotonin producing cells. In bovine Peyer¿s patches, PrPc was distributed in extrafollicular areas, but not in the germinal centre of the jejunum and ileum. PrPc was expressed in myeloid lineage cells such as myeloid dendritic cells and macrophages. In mice, PrPc was expressed in some epithelial cells throughout the small intestine as well as in cells such as follicular dendritic cell in the germinal centre of Peyer¿s patches. In this study, we demonstrate that there are a number of differences in the localization of PrPc between the murine and bovine small intestines. en
dc.format.extent 11 en
dc.language.iso eng
dc.relation.ispartof Histochemistry and Cell Biology en
dc.title Immunohistochemical characterization of cell types expressing the cellular prion protein in the small intestine of cattle and mice en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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