Isolation synthesis and glycosidase inhibition profile of 3-epi-casuarine

H...............H

Show simple item record

dc.contributor.author Nash, Robert J.
dc.contributor.author Evinson, Emma L.
dc.contributor.author Horne, Graeme
dc.contributor.author Fleet, George W. J.
dc.contributor.author Dwek, R. A.
dc.contributor.author Ameijde, Jeroen V.
dc.contributor.author Jones, Paul W.
dc.contributor.author Wormald, M. R.
dc.date.accessioned 2009-07-21T11:05:00Z
dc.date.available 2009-07-21T11:05:00Z
dc.date.issued 2006-10-31
dc.identifier.citation Nash , R J , Evinson , E L , Horne , G , Fleet , G W J , Dwek , R A , Ameijde , J V , Jones , P W & Wormald , M R 2006 , ' Isolation synthesis and glycosidase inhibition profile of 3-epi-casuarine ' Tetrahedron: Asymmetry , pp. 2702-2712 . en
dc.identifier.issn 1362-511X
dc.identifier.other PURE: 112567
dc.identifier.other dspace: 2160/2687
dc.identifier.uri http://hdl.handle.net/2160/2687
dc.description Ameijde, J. V., Horne, G., Wormald, M. R., Dwek, R. A., Nash, R. J., Jones, P. W., Evinson, E. L., Fleet, G. W. J. (2006). Isolation synthesis and glycosidase inhibition profile of 3-epi-casuarine. Tetrahedron: Asymmetry, 17, 2702-2712. en
dc.description.abstract 3-epi-Casuarine, the first naturally occurring stereoisomer of casuarine, was isolated from Myrtus communis L. The glycosidase inhibition profile and NMR spectra of 3-epi-casuarine are compared with those of casuarine; the change in configuration at one of the six stereogenic centres causes a dramatic change in the conformation of the bicyclic system. The key step in the 6% overall yield synthesis of 3-epi-casuarine from d-gluconolactone is the efficient cyclization of a completely unprotected pentahydroxyaminomesylate to the pyrrolizidine nucleus. A low yield synthesis of casuarine is also reported. en
dc.format.extent 11 en
dc.language.iso eng
dc.relation.ispartof Tetrahedron: Asymmetry en
dc.title Isolation synthesis and glycosidase inhibition profile of 3-epi-casuarine en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1016/j.tetasy.2006.10.005
dc.contributor.institution Aberystwyth University en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Cadair


Advanced Search

Browse

My Account