An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum

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dc.contributor.author Gibbons, S.
dc.contributor.author Griffith, Gareth W.
dc.contributor.author Hedger, John N.
dc.contributor.author Stavri, M.
dc.contributor.author Brayford, D.
dc.contributor.author Smith, E.
dc.contributor.author O'Donnell, G.
dc.contributor.author Evans, L.
dc.contributor.author Gray, A. I.
dc.date.accessioned 2009-07-21T14:19:01Z
dc.date.available 2009-07-21T14:19:01Z
dc.date.issued 2009-07-21
dc.identifier.citation Gibbons , S , Griffith , G W , Hedger , J N , Stavri , M , Brayford , D , Smith , E , O'Donnell , G , Evans , L & Gray , A I 2009 , ' An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum ' Phytochemistry , pp. 2110-2114 . en
dc.identifier.other PURE: 121766
dc.identifier.other dspace: 2160/2695
dc.identifier.uri http://hdl.handle.net/2160/2695
dc.description Evans, L., Hedger, J. N., Brayford, D., Stavri, M., Smith, E., O'Donnell, G., Gray, A. I., Griffith,. G. W., Gibbons, S. (2006).. An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum . Phytochemistry, 67, (19), 2110-2114. Keywords: Acremonium crotocinigenum; Fusidane triterpene; Fusidic acid; Antibacterial; MRSA; MDR; Staphylococcus aureus en
dc.description.abstract A fusidane triterpene, 16-deacetoxy-7-¿-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all 1H and 13C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra. Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 ¿g/ml. Bioautography-led isolation of an extract of the fermentation of the mitosporic fungus Acremonium crotocinigenum resulted in the characterisation of the fusidane triterpene related to fusidic acid, 1, as the major anti-staphylococcal natural product. Against efflux strains, 1 had MIC values of 16 ¿g/ml. en
dc.format.extent 5 en
dc.language.iso eng
dc.relation.ispartof Phytochemistry en
dc.title An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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