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dc.contributor.author Allgrove, Judith
dc.contributor.author Gleeson, Michael
dc.contributor.author Davison, Glen
dc.date.accessioned 2009-08-04T18:15:36Z
dc.date.available 2009-08-04T18:15:36Z
dc.date.issued 2009-05
dc.identifier.citation Allgrove , J , Gleeson , M & Davison , G 2009 , ' Salivary antimicrobial peptides (LL-37 and alpha-defensins HNP1-3), antimicrobial and IgA responses to prolonged exercise ' European Journal of Applied Physiology , pp. 277-284 . en
dc.identifier.issn 1439-6327
dc.identifier.other PURE: 114697
dc.identifier.other dspace: 2160/2759
dc.identifier.uri http://hdl.handle.net/2160/2759
dc.identifier.uri http://www.springerlink.com/content/k685611874h4t4k2/ en
dc.description Davison, G., Allgrove, J., and Gleeson, M. (2009). Salivary antimicrobial peptides (LL-37 and alpha-defensins HNP1-3), antimicrobial and IgA responses to prolonged exercise. European Journal of Applied Physiology, 106, 277-284. en
dc.description.abstract There are many factors in mucosal secretions that contribute to innate immunity and the ‘first line of defence’ at mucosal surfaces. Few studies, however, have investigated the effects of exercise on many of these ‘defence’ factors. The aim of the present study was to determine the acute effects of prolonged exercise on salivary levels of selected antimicrobial peptides (AMP) that have not yet been studied in response to exercise (HNP1–3 and LL-37) in addition to immunoglobulin A (IgA). A secondary objective was to assess the effects of exercise on saliva antibacterial capacity. Twelve active men exercised on a cycle ergometer for 2.5 h at ~60% of maximal oxygen uptake. Unstimulated whole saliva samples were obtained before and after exercise. There was a significant decrease (P <0.05) in salivary IgA:osmolality ratio, following exercise, but IgA concentration and secretion rate were unaltered. Salivary HNP1–3 and LL-37 concentrations (P <0.01 and P <0.05, respectively), concentration:osmolality ratios (P <0.01) and secretion rates (P <0.01) all increased following exercise. Salivary antibacterial capacity (against E. coli) did not change. The increased concentration of AMPs in saliva may confer some benefit to the ‘first line of defence’ and could result from synergistic compensation within the mucosal immune system and/or airway inflammation and epithelial damage. Further study is required to determine the significance of such changes on the overall ‘defence’ capacity of saliva and how this influences the overall risk for infection. en
dc.format.extent 8 en
dc.language.iso eng
dc.relation.ispartof European Journal of Applied Physiology en
dc.title Salivary antimicrobial peptides (LL-37 and alpha-defensins HNP1-3), antimicrobial and IgA responses to prolonged exercise en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.contributor.institution Department of Sport & Exercise Science en
dc.description.status Peer reviewed en


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