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dc.contributor.author Atsushi en_US
dc.contributor.author Robert J. en_US
dc.contributor.author Naoki en_US
dc.contributor.author T. en_US
dc.contributor.author Haruhisa en_US
dc.contributor.author Y. en_US
dc.contributor.author Isao en_US
dc.contributor.author H. en_US
dc.contributor.author Jackie en_US
dc.date.accessioned 2009-08-10T10:19:20Z
dc.date.available 2009-08-10T10:19:20Z
dc.date.issued 2006-08-05 en_US
dc.identifier http://dx.doi.org/10.1021/jf061599a en_US
dc.identifier.citation Kato , A , Nash , R J , Asano , N , Okamoto , T , Kizu , H , Higuchi , Y , Adachi , I , Goto , H & Hollinshead , J 2006 , ' Inhibitory effects of Zingiber officinale roscoe derived components on aldose reductase activity in vitro and in vivo ' Journal of Agricultural and Food Chemistry , pp. 6640-6644 . , 10.1021/jf061599a en_US
dc.identifier.other PURE: 110295 en_US
dc.identifier.other dspace: 2160/2814 en_US
dc.identifier.uri http://hdl.handle.net/2160/2814
dc.description.abstract Ginger (Zingiber officinale Roscoe) continues to be used as an important cooking spice and herbal medicine around the world. Scientific research has gradually verified the antidiabetic effects of ginger. Especially gingerols, which are the major components of ginger, are known to improve diabetes including the effect of enhancement against insulin-sensitivity. Aldose reductase inhibitors have considerable potential for the treatment of diabetes, without increased risk of hypoglycemia. The assay for aldose reductase inhibitors in ginger led to the isolation of five active compounds including 2-(4-hydroxy-3-methoxyphenyl)ethanol (2) and 2-(4-hydroxy-3-methoxyphenyl)ethanoic acid (3). Compounds 2 and 3 were good inhibitors of recombinant human aldose reductase, with IC50 values of 19.2 ± 1.9 and 18.5 ± 1.1 μM, respectively. Furthermore, these compounds significantly suppressed not only sorbitol accumulation in human erythrocytes but also lens galactitol accumulation in 30% of galactose-fed cataract rat model. A structure−activity relationship study revealed that the applicable side alkyl chain length and the presence of a C3 OCH3 group in the aromatic ring are essential features for enzyme recognition and binding. These results suggested that it would contribute to the protection against or improvement of diabetic complications for a dietary supplement of ginger or its extract containing aldose reductase inhibitors. en_US
dc.format.extent 5 en_US
dc.relation.ispartof Journal of Agricultural and Food Chemistry en_US
dc.title Inhibitory effects of Zingiber officinale roscoe derived components on aldose reductase activity in vitro and in vivo en_US
dc.contributor.pbl Aberystwyth University en_US
dc.contributor.pbl Institute of Biological, Environmental and Rural Sciences en_US


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