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dc.contributor.author Kato, Atsushi
dc.contributor.author Nash, Robert J.
dc.contributor.author Asano, Naoki
dc.contributor.author Okamoto, T.
dc.contributor.author Kizu, Haruhisa
dc.contributor.author Higuchi, Y.
dc.contributor.author Adachi, Isao
dc.contributor.author Goto, H.
dc.contributor.author Hollinshead, Jackie
dc.date.accessioned 2009-08-10T10:19:20Z
dc.date.available 2009-08-10T10:19:20Z
dc.date.issued 2006-08-05
dc.identifier.citation Kato , A , Nash , R J , Asano , N , Okamoto , T , Kizu , H , Higuchi , Y , Adachi , I , Goto , H & Hollinshead , J 2006 , ' Inhibitory effects of Zingiber officinale roscoe derived components on aldose reductase activity in vitro and in vivo ' Journal of Agricultural and Food Chemistry , pp. 6640-6644 . , 10.1021/jf061599a en
dc.identifier.issn 1520-5118
dc.identifier.other PURE: 110295
dc.identifier.other dspace: 2160/2814
dc.identifier.uri http://hdl.handle.net/2160/2814
dc.description Kato, A., Higuchi, Y., Goto, H., Kizu, H., Okamoto, T., Asano, N., Hollinshead, J., Nash, R. J., Adachi, I. (2006). Inhibitory effects of Zingiber officinale roscoe derived components on aldose reductase activity in vitro and in vivo. Journal of Agricultural and Food Chemistry, 54, (18), 6640-6644. en
dc.description.abstract Ginger (Zingiber officinale Roscoe) continues to be used as an important cooking spice and herbal medicine around the world. Scientific research has gradually verified the antidiabetic effects of ginger. Especially gingerols, which are the major components of ginger, are known to improve diabetes including the effect of enhancement against insulin-sensitivity. Aldose reductase inhibitors have considerable potential for the treatment of diabetes, without increased risk of hypoglycemia. The assay for aldose reductase inhibitors in ginger led to the isolation of five active compounds including 2-(4-hydroxy-3-methoxyphenyl)ethanol (2) and 2-(4-hydroxy-3-methoxyphenyl)ethanoic acid (3). Compounds 2 and 3 were good inhibitors of recombinant human aldose reductase, with IC50 values of 19.2 ± 1.9 and 18.5 ± 1.1 μM, respectively. Furthermore, these compounds significantly suppressed not only sorbitol accumulation in human erythrocytes but also lens galactitol accumulation in 30% of galactose-fed cataract rat model. A structure−activity relationship study revealed that the applicable side alkyl chain length and the presence of a C3 OCH3 group in the aromatic ring are essential features for enzyme recognition and binding. These results suggested that it would contribute to the protection against or improvement of diabetic complications for a dietary supplement of ginger or its extract containing aldose reductase inhibitors. en
dc.format.extent 5 en
dc.language.iso eng
dc.relation.ispartof Journal of Agricultural and Food Chemistry en
dc.title Inhibitory effects of Zingiber officinale roscoe derived components on aldose reductase activity in vitro and in vivo en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1021/jf061599a
dc.contributor.institution Aberystwyth University en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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