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dc.contributor.author Harris, Llinos G.
dc.contributor.author ap Gwynn, Iolo A.
dc.contributor.author Bacon, Claire
dc.contributor.author Richards, R. Geoff
dc.contributor.author Patterson, Louisa M.
dc.date.accessioned 2009-09-08T10:34:07Z
dc.date.available 2009-09-08T10:34:07Z
dc.date.issued 2005-04-01
dc.identifier.citation Harris , L G , ap Gwynn , I A , Bacon , C , Richards , R G & Patterson , L M 2005 , ' Assessment of the cytocompatibility of different coated titanium surfaces to fibroblasts and osteoblasts ' Journal of Biomedical Materials Research Part A , vol 73A , no. 1 , pp. 12-20 . , 10.1002/jbm.a.30276 en
dc.identifier.issn 1552-4965
dc.identifier.other PURE: 117979
dc.identifier.other dspace: 2160/2991
dc.identifier.uri http://hdl.handle.net/2160/2991
dc.description Harris, L. G., Patterson, L. M., Bacon, C., ap Gwynn, I., Richards, R. G. (2005). Assessment of the cytocompatibility of different coated titanium surfaces to fibroblasts and osteoblasts.  Journal of Biomedical Materials Research Part A, 73A, (1), 12-20 en
dc.description.abstract Over the years, many metal and polymer implants have been developed for internal fracture fixation. However, there are always some problems associated with their application, such as implant loosening or infection. This study describes how the morphology and adhesion of both fibroblasts and osteoblasts to two manufactured commercially pure, medical implant-quality anodized titanium surfaces (TS and TSS), and five modified titanium surfaces (TLF, low friction gray anodized titanium; TIG, nitrogen ion implanted TSS; THY, TSS grafted with sodium hyaluronate; TAST, TSS coated with hydrophilic hydrogel; and TT, tiodized TS) were used to obtain an indication of their relative cytocompatibility and to assess which modified surface could potentially be used in vivo. Small variations were observed both qualitatively and quantitatively in the spreading and adhesion of fibroblasts and osteoblasts to the studied surfaces. Overall, fibroblast spreading and adhesion were greatest on the TIG and TLF surfaces. Osteoblast spreading and adhesion were greatest on TS, TIG, and TAST surfaces. No fibroblasts or osteoblasts were found attached to the THY-coated surfaces. Coating medical implant-quality anodized titanium surfaces (TS and TSS) with a TLF, TAST, or more specifically TIG could probably improve soft tissue adhesion and/or osseointegration of bone in vivo. However, it seemed that a hyaluronic acid coating (THY) has potential as a coating in areas where cell adhesion is undesirable, such as orbital fractures, where muscles should avoid adhesion to the implant, and distal radius fractures, where tendons should freely glide over the implant en
dc.format.extent 9 en
dc.language.iso eng
dc.relation.ispartof Journal of Biomedical Materials Research Part A en
dc.subject fibroblasts en
dc.subject osteoblasts en
dc.subject titanium en
dc.subject coating en
dc.subject adhesion en
dc.subject immunolabeling en
dc.subject vinculin en
dc.title Assessment of the cytocompatibility of different coated titanium surfaces to fibroblasts and osteoblasts en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1002/jbm.a.30276
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.contributor.institution Institute of Geography & Earth Sciences en
dc.description.status Peer reviewed en


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