| dc.contributor.author |
Nash, Robert J. |
|
| dc.contributor.author |
Asano, Naoki |
|
| dc.contributor.author |
Winters, Ana L. |
|
| dc.contributor.author |
Yu, C. Y. |
|
| dc.contributor.author |
Fleet, George W. J. |
|
| dc.contributor.author |
Butters, T. D. |
|
| dc.contributor.author |
Ikeda, Kyoko |
|
| dc.contributor.author |
Dwek, R. A. |
|
| dc.contributor.author |
Wormald, M. R. |
|
| dc.contributor.author |
Wang, M. X. |
|
| dc.date.accessioned |
2009-09-24T11:11:33Z |
|
| dc.date.available |
2009-09-24T11:11:33Z |
|
| dc.date.issued |
2004-07-29 |
|
| dc.identifier.citation |
Nash , R J , Asano , N , Winters , A L , Yu , C Y , Fleet , G W J , Butters , T D , Ikeda , K , Dwek , R A , Wormald , M R & Wang , M X 2004 , ' Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP ' Chemical Communications , pp. 1936-1937 . |
en |
| dc.identifier.other |
PURE: 121421 |
|
| dc.identifier.other |
dspace: 2160/3071 |
|
| dc.identifier.uri |
http://hdl.handle.net/2160/3071 |
|
| dc.description |
Yu, C. Y., Asano, N., Ikeda, K., Wang, M. X., Butters, T. D., Wormald, M. R., Dwek, R. A., Winters, A. L., Nash, R. J., Fleet, G. W. J. (2004). Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP. Chemical Communications, 17, 1936-1937. Sponsorship: Royal Society of London/Chinese Academy of Sciences |
en |
| dc.description.abstract |
L-DMDP, prepared from D-gulonolactone, is a highly specific inhibitor of a number of plant and mammalian -glucosidases [between 2 and 4 orders of magnitude more potent than the enantiomeric natural product DMDP] but is not an inhibitor of bacterial and yeast -glucosidases. Additionally N-butyl-DMDP is a potent inhibitor of ceramide-specific glucosyltransferase but N-butyl-L-DMDP shows no inhibition. |
en |
| dc.format.extent |
2 |
en |
| dc.language.iso |
eng |
|
| dc.relation.ispartof |
Chemical Communications |
en |
| dc.title |
Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP |
en |
| dc.type |
Text |
en |
| dc.type.publicationtype |
Article (Journal) |
en |
| dc.identifier.doi |
http://dx.doi.org/10.1039/b406035k |
|
| dc.contributor.institution |
Institute of Biological, Environmental and Rural Sciences |
en |
| dc.description.status |
Peer reviewed |
en |