The use of non-prion biomarkers for the diagnosis of bovine spongiform encephalopathy and scrapie in the live animal

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dc.contributor.author Parveen, Ifat
dc.contributor.author Moorby, Jon M.
dc.contributor.author Allison, Gordon G.
dc.contributor.author Jackman, Roy
dc.date.accessioned 2009-09-24T13:22:27Z
dc.date.available 2009-09-24T13:22:27Z
dc.date.issued 2005
dc.identifier.citation Parveen , I , Moorby , J M , Allison , G G & Jackman , R 2005 , ' The use of non-prion biomarkers for the diagnosis of bovine spongiform encephalopathy and scrapie in the live animal ' Veterinary Research , vol 36 , no. 5-6 , pp. 665-683 . en
dc.identifier.issn 1297-9716
dc.identifier.other PURE: 119008
dc.identifier.other dspace: 2160/3081
dc.identifier.uri http://hdl.handle.net/2160/3081
dc.description Parveen, I., Moorby, J. M., Allison, G. G., Jackman, R. (2005). The use of non-prion biomarkers for the diagnosis of bovine spongiform encephalopathy and scrapie in the live animal. Veterinary Research (Paris), 36 (5-6), 665-683. Sponsorship: UK Food Standards Agency / DEFRA en
dc.description.abstract Scrapie and bovine spongiform encephalopathy (BSE) are major global concerns and the emergence of variant Creutzfeldt-Jakob disease (vCJD) has caused turmoil for blood transfusion services and hospitals worldwide. Recent reports of iatrogenic CJD (iCJD) cases following blood transfusions from Transmissible Spongiform Encephalopathies (TSE)-infected donors have fuelled this concern. Major diagnostic tests for BSE and scrapie are conducted post-mortem from animals in late stages of the disease. Although the lymphoreticular system is involved in the earlier pathogenesis of some forms of sheep scrapie and vCJD, which presents great opportunity for diagnostic development, other TSE diseases (some strains of scrapie, sporadic CJD (sCJD) and bovine BSE) do not present such a diagnostic opportunity. Thus, there is an urgent need for pre-mortem tests that differentiate between healthy and diseased individuals at early stages of illness, in accessible samples such as blood and urine using less invasive procedures. This review reports on the current state of progress in the development and use of prion and non-prion biomarkers in the diagnosis of TSE diseases. Some of these efforts have concentrated on improving the sensitivity of PrPSc detection to allow in vivo diagnosis at low abundances of PrPSc whilst others have sought to identify non-prion protein biomarkers of TSE disease, many of which are still at early stages of development. In this review we comment upon the limitations of prion based tests and review current research on the development of tests for TSE that rely on non-prion disease markers in body fluids that may allow preclinical disease diagnosis. en
dc.language.iso eng
dc.relation.ispartof Veterinary Research en
dc.title The use of non-prion biomarkers for the diagnosis of bovine spongiform encephalopathy and scrapie in the live animal en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1051/vetres:2005028
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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