Mechanisms for mechanical damage in the intervertebral disc annulus fibrosus

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dc.contributor.author ap Gwynn, Iolo A.
dc.contributor.author Iatridis, J. C.
dc.date.accessioned 2009-09-25T13:35:45Z
dc.date.available 2009-09-25T13:35:45Z
dc.date.issued 2004
dc.identifier.citation ap Gwynn , I A & Iatridis , J C 2004 , ' Mechanisms for mechanical damage in the intervertebral disc annulus fibrosus ' Journal of Biomechanics , vol 37 , no. 8 , pp. 1165-1175 . en
dc.identifier.issn 0021-9290
dc.identifier.other PURE: 121084
dc.identifier.other dspace: 2160/3086
dc.identifier.uri http://hdl.handle.net/2160/3086
dc.description Iatridis, J. C., ap Gwynn, I. (2004). Mechanisms for mechanical damage in the intervertebral disc annulus fibrosus.   Journal of Biomechanics, 37, (8), 1165-1175 Keywords: Intervertebral disc, Annulus fibrosus, Collagen fiber damage, Interlaminar shear stress, Delamination en
dc.description.abstract Intervertebral disc degeneration results in disorganization of the laminate structure of the annulus that may arise from mechanical microfailure. Failure mechanisms in the annulus were investigated using composite lamination theory and other analyses to calculate stresses in annulus layers, interlaminar shear stress, and the region of stress concentration around a fiber break. Scanning electron microscopy (SEM) was used to evaluate failure patterns in the annulus and evaluate novel structural features of the disc tissue. Stress concentrations in the annulus due to an isolated fiber break were localized to approximately 5μm away from the break, and only considered a likely cause of annulus fibrosus failure (i.e., radial tears in the annulus) under extreme loading conditions or when collagen damage occurs over a relatively large region. Interlaminar shear stresses were calculated to be relatively large, to increase with layer thickness (as reported with degeneration), and were considered to be associated with propagation of circumferential tears in the annulus. SEM analysis of intervertebral disc annulus fibrosus tissue demonstrated a clear laminate structure, delamination, matrix cracking, and fiber failure. Novel structural features noted with SEM also included the presence of small tubules that appear to run along the length of collagen fibers in the annulus and a distinct collagenous structure representative of a pericellular matrix in the nucleus region. en
dc.format.extent 11 en
dc.language.iso eng
dc.relation.ispartof Journal of Biomechanics en
dc.subject Intervertebral disc en
dc.subject Annulus fibrosus en
dc.subject Collagen fiber damage en
dc.subject Interlaminar shear stress en
dc.subject Delamination en
dc.title Mechanisms for mechanical damage in the intervertebral disc annulus fibrosus en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1016/j.jbiomech.2003.12.026
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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