Binding of hematin to a new class of glutathione transferase from the blood-feeding parasitic nematode Haemonchus contortus.

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dc.contributor.author Brophy, Peter M.
dc.contributor.author Jefferies, James R.
dc.contributor.author Teesdale-Spittle, Paul
dc.contributor.author Tait, Andrew
dc.contributor.author van Rossum, Arjan J.
dc.contributor.author LaCourse, E. James
dc.contributor.author Rijsewijk, Frans A. M.
dc.contributor.author Barrett, John
dc.date.accessioned 2009-10-06T11:14:45Z
dc.date.available 2009-10-06T11:14:45Z
dc.date.issued 2004-05
dc.identifier.citation Brophy , P M , Jefferies , J R , Teesdale-Spittle , P , Tait , A , van Rossum , A J , LaCourse , E J , Rijsewijk , F A M & Barrett , J 2004 , ' Binding of hematin to a new class of glutathione transferase from the blood-feeding parasitic nematode Haemonchus contortus. ' Infection and Immunity , pp. 2780-2790 . en
dc.identifier.issn 1098-5522
dc.identifier.other PURE: 122293
dc.identifier.other dspace: 2160/3152
dc.identifier.uri http://hdl.handle.net/2160/3152
dc.identifier.uri http://iai.asm.org/cgi/reprint/72/5/2780 en
dc.description Arjan J. van Rossum, James R. Jefferies, Frans A. M. Rijsewijk, E. James LaCourse, Paul Teesdale-Spittle, John Barrett, Andrew Tait, and Peter M. Brophy (2004). Binding of hematin by a new class of glutathione transferase from the blood-feeding parasitic nematode Haemonchus contortus. Infection and Immunity, 72 (5), 2780-2790. Sponsorship: EU / BBSRC RAE2008 en
dc.description.abstract The phase II detoxification system glutathione transferase (GST) is associated with the establishment of parasitic nematode infections within the gastrointestinal environment of the mammalian host. We report the functional analysis of a GST from an important worldwide parasitic nematode of small ruminants, Haemonchus contortus. This GST shows limited activity with a range of classical GST substrates but effectively binds hematin. The high-affinity binding site for hematin was not present in the GST showing the most identity, CE07055 from the free-living nematode Caenorhabditis elegans. This finding suggests that the high-affinity binding of hematin may represent a parasite adaptation to blood or tissue feeding from the host. en
dc.format.extent 11 en
dc.language.iso eng
dc.relation.ispartof Infection and Immunity en
dc.title Binding of hematin to a new class of glutathione transferase from the blood-feeding parasitic nematode Haemonchus contortus. en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1128/IAI.72.5.2780-2790.2004
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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