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dc.contributor.author Ohwada, Shyuichi
dc.contributor.author Rose, Michael T.
dc.contributor.author Aso, Hisashi
dc.contributor.author Watanabe, Shinichiro
dc.contributor.author Hayashi, Shinichiro
dc.contributor.author Nara, Hidetoshi
dc.contributor.author Yamaguchi, Takahiro
dc.date.accessioned 2009-10-17T12:36:20Z
dc.date.available 2009-10-17T12:36:20Z
dc.date.issued 2009-10-17
dc.identifier.citation Ohwada , S , Rose , M T , Aso , H , Watanabe , S , Hayashi , S , Nara , H & Yamaguchi , T 2009 , ' Sequence of IGF-I, IGF-II, and HGF expression in regenerating skeletal muscle ' Unknown Journal , pp. 427-434 . en
dc.identifier.other PURE: 132622
dc.identifier.other dspace: 2160/3240
dc.identifier.uri http://hdl.handle.net/2160/3240
dc.description Hayashi, T., Aso, H., Watanabe, K., Nara, H., Rose, M. T., Ohwada, S., Yamaguchi, T. (2004). Sequence of IGF-I, IGF-II, and HGF expression in regenerating skeletal muscle   Histochemistry and Cell Biology, 122, (5), 427-434. en
dc.description.abstract Various cytokines are thought to play a role in muscle regeneration, however, the interaction and mechanisms of action of these cytokines remains largely unknown. In this study, we investigated the role of HGF, IGF-I, and IGF-II during myogenesis using the regeneration model of skeletal muscle as well as myoblast culture. RT-PCR analysis revealed that HGF and IGF-I expressions were markedly upregulated, in regenerating muscle. In contrast, there was no significant difference in IGF-II expression between normal and regenerating muscle. Immunohistochemical analysis demonstrated that HGF was expressed mostly by myocytes during the early stages of muscle regeneration. Additionally, HGF inhibited the formation of myotubes by myoblasts, but promoted cellular proliferation. Otherwise, IGF-I and IGF-II were expressed by myocytes through the early to middle stages of muscle regeneration. The addition of HGF to myoblast growing in vitro significantly increased the number of cells. These findings indicate that these three cytokines have pleiotropic effects in regenerating skeletal muscle. en
dc.format.extent 8 en
dc.language.iso eng
dc.relation.ispartof Unknown Journal en
dc.title Sequence of IGF-I, IGF-II, and HGF expression in regenerating skeletal muscle en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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