Show simple item record Atsushi en_US Heui S. en_US Haruhisa en_US Yukihiko en_US Kyoko en_US Robert J. en_US Kayo en_US Kang S. en_US Naoki en_US Toru en_US 2009-11-02T11:26:59Z 2009-11-02T11:26:59Z 2001-08-16 en_US
dc.identifier en_US
dc.identifier.citation Kato , A , Lee , H S , Kizu , H , Kameda , Y , Ikeda , K , Nash , R J , Yasuda , K , Ryu , K S , Asano , N & Yamashita , T 2001 , ' Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.) ' Journal of Agricultural and Food Chemistry , vol 49 , no. 9 , pp. 4208-4213 . , 10.1021/jf010567e en_US
dc.identifier.other PURE: 126210 en_US
dc.identifier.other dspace: 2160/3362 en_US
dc.description.abstract New polyhydroxylated alkaloids, (2R,3R,4R)-2-hydroxymethyl-3,4-dihydroxypyrrolidine-N-propionamide from the root bark of Morus alba L., and 4-O-α-d-galactopyranosyl-calystegine B2 and 3β,6β-dihydroxynortropane from the fruits, were isolated by column chromatography using a variety of ion-exchange resins. Fifteen other polyhydroxylated alkaloids were also isolated. 1-Deoxynojirimycin, a potent α-glucosidase inhibitor, was concentrated 2.7-fold by silkworms feeding on mulberry leaves. Some alkaloids contained in mulberry leaves were potent inhibitors of mammalian digestive glycosidases but not inhibitors of silkworm midgut glycosidases, suggesting that the silkworm has enzymes specially adapted to enable it to feed on mulberry leaves. The possibility of preventing the onset of diabetes and obesity using natural dietary supplements containing 1-deoxynojirimycin and other α-glucosidase inhibitors in high concentration is of great potential interest. en_US
dc.format.extent 6 en_US
dc.relation.ispartof Journal of Agricultural and Food Chemistry en_US
dc.title Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.) en_US
dc.contributor.pbl Aberystwyth University en_US
dc.contributor.pbl Institute of Biological, Environmental and Rural Sciences en_US

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