Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.)

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dc.contributor.author Kato, Atsushi
dc.contributor.author Lee, Heui S.
dc.contributor.author Kizu, Haruhisa
dc.contributor.author Kameda, Yukihiko
dc.contributor.author Ikeda, Kyoko
dc.contributor.author Nash, Robert J.
dc.contributor.author Yasuda, Kayo
dc.contributor.author Ryu, Kang S.
dc.contributor.author Asano, Naoki
dc.contributor.author Yamashita, Toru
dc.date.accessioned 2009-11-02T11:26:59Z
dc.date.available 2009-11-02T11:26:59Z
dc.date.issued 2001-08-16
dc.identifier.citation Kato , A , Lee , H S , Kizu , H , Kameda , Y , Ikeda , K , Nash , R J , Yasuda , K , Ryu , K S , Asano , N & Yamashita , T 2001 , ' Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.) ' Journal of Agricultural and Food Chemistry , vol 49 , no. 9 , pp. 4208-4213 . en
dc.identifier.issn 1520-5118
dc.identifier.other PURE: 126210
dc.identifier.other dspace: 2160/3362
dc.identifier.uri http://hdl.handle.net/2160/3362
dc.description Asano, N., Yamashita, T., Yasuda, K., Ikeda, K., Kizu, H., Kameda, Y., Kato, A., Nash, R. J., Lee, H. S., Ryu, K. S. (2001). Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.).   Journal of Agricultural and Food Chemistry, 49, (9), 4208-4213. en
dc.description.abstract New polyhydroxylated alkaloids, (2R,3R,4R)-2-hydroxymethyl-3,4-dihydroxypyrrolidine-N-propionamide from the root bark of Morus alba L., and 4-O-α-d-galactopyranosyl-calystegine B2 and 3β,6β-dihydroxynortropane from the fruits, were isolated by column chromatography using a variety of ion-exchange resins. Fifteen other polyhydroxylated alkaloids were also isolated. 1-Deoxynojirimycin, a potent α-glucosidase inhibitor, was concentrated 2.7-fold by silkworms feeding on mulberry leaves. Some alkaloids contained in mulberry leaves were potent inhibitors of mammalian digestive glycosidases but not inhibitors of silkworm midgut glycosidases, suggesting that the silkworm has enzymes specially adapted to enable it to feed on mulberry leaves. The possibility of preventing the onset of diabetes and obesity using natural dietary supplements containing 1-deoxynojirimycin and other α-glucosidase inhibitors in high concentration is of great potential interest. en
dc.format.extent 6 en
dc.language.iso eng
dc.relation.ispartof Journal of Agricultural and Food Chemistry en
dc.title Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.) en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1021/jf010567e
dc.contributor.institution Aberystwyth University en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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