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dc.contributor.author Koyama, S.
dc.contributor.author Ozawa, A.
dc.contributor.author Rose, Michael T.
dc.contributor.author Matsumoto, M.
dc.contributor.author Obara, Y.
dc.contributor.author Itoh, F.
dc.contributor.author Hodate, K.
dc.date.accessioned 2009-11-02T12:02:08Z
dc.date.available 2009-11-02T12:02:08Z
dc.date.issued 2009-11-02
dc.identifier.citation Koyama , S , Ozawa , A , Rose , M T , Matsumoto , M , Obara , Y , Itoh , F & Hodate , K 2009 , ' Effects of heat exposure on adrenergic modulation of insulin and glucagon secretion in sheep ' Endocrine Journal , pp. 193-198 . en
dc.identifier.other PURE: 135494
dc.identifier.other dspace: 2160/3369
dc.identifier.uri http://hdl.handle.net/2160/3369
dc.description Itoh, F., Hodate, K., Koyama, S., Rose, M. T., Matsumoto, M., Ozawa, A., Obara, Y. (2001). Effects of heat exposure on adrenergic modulation of insulin and glucagon secretion in sheep. Endocrine Journal, 48, (2), 193-198. en
dc.description.abstract The effects of heat exposure on the adrenergic modulation of pancreatic secretion were investigated. Five ewes fed at maintenance level (ME base) were housed in thermoneutral (TN; 20°C) and hot (30°C) environments. Heat exposure caused an increase in respiration rate and a slightly higher rectal temperature, and decreases in basal insulin and glucose concentrations. Infusions of saline plus epinephrine caused increases in glucagon and glucose concentrations, and no significant change in insulin secretion. Phentolamine (an adrenergic alpha-antagonist) plus epinephrine augmented insulin secretion; however, this insulin secretory response was inhibited by heat exposure. Propranolol (a beta-antagonist) plus epinephrine produced a slight decrease in insulin secretion in the TN environment, whereas no effect was observed during heat exposure. While glucagon secretion through alpha-adrenergic stimulation was not affected by heat exposure, homeostatic signals controlling insulin release seemed to be affected during heat exposure. We thus hypothesised that insulin concentration is decreased in sheep fed at maintenance level in hot environments, and that this response is mediated in part by a modulation of beta-adrenergic function. en
dc.format.extent 6 en
dc.language.iso eng
dc.relation.ispartof Endocrine Journal en
dc.title Effects of heat exposure on adrenergic modulation of insulin and glucagon secretion in sheep en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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