Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2)

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dc.contributor.author Waterman, Michael R.
dc.contributor.author Ishikawa, Jun
dc.contributor.author Skaug, Tove
dc.contributor.author Omura, Satoshi
dc.contributor.author Nelson, David R.
dc.contributor.author Ikeda, Haruo
dc.contributor.author Jackson, Colin J.
dc.contributor.author Kelly, Steven L.
dc.contributor.author Lamb, David C.
dc.date.accessioned 2009-11-03T12:14:15Z
dc.date.available 2009-11-03T12:14:15Z
dc.date.issued 2003-08-01
dc.identifier.citation Waterman , M R , Ishikawa , J , Skaug , T , Omura , S , Nelson , D R , Ikeda , H , Jackson , C J , Kelly , S L & Lamb , D C 2003 , ' Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2) ' Biochemical and Biophysical Research Communications , vol 307 , no. 3 , pp. 610-619 . en
dc.identifier.issn 1090-2104
dc.identifier.other PURE: 139457
dc.identifier.other dspace: 2160/3409
dc.identifier.uri http://hdl.handle.net/2160/3409
dc.description Lamb, D.C., Ikeda, H., Nelson, D.R., Ishikawa, J., Skaug, T., Jackson, C., Omura, S., Waterman, M.R., Kelly, S.L. (2003). Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2).   Biochemical and Biophysical Research Communications, 307, (3), 610-619. Sponsorship: Biotechnological and Biological Sciences Research Council; Wellcome Trust en
dc.description.abstract The genus Streptomyces produces about two-thirds of naturally occurring antibiotics and a wide array of other secondary metabolites, including antihelminthic agents, antitumor agents, antifungal agents, and herbicides. The newly completed genome sequence of the avermectin-producing bacterium Streptomyces avermitilis contains 33 cytochromes P450 (CYPs), many more than the 18 observed in Streptomyces coelicolor A3(2). Some of the likely metabolic functions are reported together with their genomic location and bioinformatic analysis. Seven entirely new CYP families were found together with close homologues of some forms observed in S. coelicolor A3(2). The presence of unusual CYP forms associated with conservons is revealed and of these, CYP157 forms in both S. avermitilis and S. coelicolor A3(2) deviate from the previously accepted rule for an EXXR motif within the K-helix of CYPs. Amongst this range of CYPs are forms associated with avermectin, filipin, geosmin, and pentalenolactone biosynthesis as well as unknown pathways of secondary metabolism. en
dc.format.extent 10 en
dc.language.iso eng
dc.relation.ispartof Biochemical and Biophysical Research Communications en
dc.subject Streptomyces en
dc.subject Genome en
dc.subject Cytochrome P450 en
dc.subject Secondary metabolism en
dc.subject Antibiotics en
dc.subject Evolution en
dc.title Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2) en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1016/S0006-291X(03)01231-2
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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