Biochemical characterisation of a hydrophobic ligand binding protein from the tapeworm Hymenolepis diminuta

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dc.contributor.author Brophy, Peter M.
dc.contributor.author Barrett, John
dc.contributor.author Saghir, N.
dc.contributor.author Conde, Phillip J.
dc.date.accessioned 2009-11-05T14:39:21Z
dc.date.available 2009-11-05T14:39:21Z
dc.date.issued 2001-05-15
dc.identifier.citation Brophy , P M , Barrett , J , Saghir , N & Conde , P J 2001 , ' Biochemical characterisation of a hydrophobic ligand binding protein from the tapeworm Hymenolepis diminuta ' International Journal for Parasitology , vol 31 , no. 7 , pp. 653-660 . , 10.1016/S0020-7519(01)00135-7 en
dc.identifier.issn 0020-7519
dc.identifier.other PURE: 127265
dc.identifier.other dspace: 2160/3432
dc.identifier.uri http://hdl.handle.net/2160/3432
dc.description Saghir, N., Conde, P. J., Brophy, P. M., Barrett, J. (2001). Biochemical characterisation of a hydrophobic ligand binding protein from the tapeworm Hymenolepis diminuta.  International Journal for Parasitology, 31, (7), 653-660 Sponsorship: Wellcome Trust (047546); BBSRC en
dc.description.abstract The cestode Hymenolepis diminuta contains an abundant, cytoplasmic, hydrophobic ligand, binding protein (H-HLBP). Studies with polarity sensitive probes suggest a single hydrophobic binding site, the results also indicate that the single tryptophan in the molecule (Trp41) is involved in ligand binding. Of the possible physiological ligands tested, only haematin and retinoids (retinol and retinoic acid) show appreciable binding in addition to fatty acids. H-HLBP also binds a range of anthelmintics, again with KD values in the nM range. The interaction of anthelmintics with hydrophobic binding proteins may be important in determining drug specificity and site of action and could have a role in the development of drug resistance. en
dc.format.extent 8 en
dc.language.iso eng
dc.relation.ispartof International Journal for Parasitology en
dc.subject Hydrophobic ligand binding protein en
dc.subject Hymenolepis diminuta; Cestoda en
dc.subject 11-[5-dimethylaminonaphthalene-1-sulphonyl amino] undecanoic acid (DAUDA) en
dc.subject Anthelmintic en
dc.title Biochemical characterisation of a hydrophobic ligand binding protein from the tapeworm Hymenolepis diminuta en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1016/S0020-7519(01)00135-7
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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