Electrophysiological analysis of responses of adult females of Brugia pahangi to some chemicals

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dc.contributor.author Perry, Roland N.
dc.contributor.author Barrett, John
dc.contributor.author Rolfe, R. N.
dc.date.accessioned 2009-11-23T12:17:06Z
dc.date.available 2009-11-23T12:17:06Z
dc.date.issued 2001
dc.identifier.citation Perry , R N , Barrett , J & Rolfe , R N 2001 , ' Electrophysiological analysis of responses of adult females of Brugia pahangi to some chemicals ' Parasitology , pp. 347-357 . en
dc.identifier.issn 1469-8161
dc.identifier.other PURE: 129920
dc.identifier.other dspace: 2160/3582
dc.identifier.uri http://hdl.handle.net/2160/3582
dc.description Rolfe, R. N., Barrett, J., Perry, R. N. (2001). Electrophysiological analysis of responses of adult females of Brugia pahangi to some chemicals. Parasitology, 122,(3), 347-357. Sponsorship: BBSRC en
dc.description.abstract Electrophysiological techniques were used to obtain recordings of extracellular electrical activity from the anterior end of live adult females of Brugia pahangi. Stimulation with 100mM, 10mM and 1mM acetylcholine resulted in an increase in spike activity which was concentration dependent, whereas stimulation with phosphate-buffered saline and 0·1mM acetylcholine gave no increase in activity. The delay in response was not concentration dependent. The action of possible host cues was investigated. Stimulation with heat-inactivated foetal calf serum (IFCS) and 10mM glutathione gave an increase in spike activity but exposure to 5mg/dl haemoglobin elicited no response. The response to IFCS was found to be suppressed completely by pre-incubation for 30min in ivermectin. en
dc.format.extent 11 en
dc.language.iso eng
dc.relation.ispartof Parasitology en
dc.title Electrophysiological analysis of responses of adult females of Brugia pahangi to some chemicals en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1017/S0031182001007375
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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