The effects of acute vitamin C supplementation on cortisol, interleukin-6, and neutrophil responses to prolonged cycling exercise

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dc.contributor.author Davison, Glen
dc.contributor.author Gleeson, Michael
dc.date.accessioned 2009-11-23T15:20:58Z
dc.date.available 2009-11-23T15:20:58Z
dc.date.issued 2007
dc.identifier.citation Davison , G & Gleeson , M 2007 , ' The effects of acute vitamin C supplementation on cortisol, interleukin-6, and neutrophil responses to prolonged cycling exercise ' European Journal of Sport Science , pp. 15-25 . en
dc.identifier.issn 1536-7290
dc.identifier.other PURE: 142238
dc.identifier.other dspace: 2160/3583
dc.identifier.uri http://hdl.handle.net/2160/3583
dc.identifier.uri http://www.informaworld.com/smpp/content~db=all~content=a777752692 en
dc.description Davison, G. and Gleeson, M. (2007). The effects of acute vitamin C supplementation on cortisol, interleukin-6, and neutrophil responses to prolonged cycling exercise. European Journal of Sport Science, 7, 15-25. en
dc.description.abstract The depression of immune cell function that is typically observed after prolonged exercise is thought to be largely mediated by increased concentrations of stress hormones and cytokines as well as, possibly, oxidative stress. The aim of this study was to measure immunoendocrine responses, with acute vitamin C or placebo ingestion, before and during prolonged exercise. In a single-blind, randomized, counterbalanced/crossover design, eight healthy males ingested a bolus of 500 mg and 1000 mg vitamin C 2 h and 14 h pre-exercise respectively, then cycled for 2 h at approximately 60% maximal oxygen uptake (VO2max). They also consumed either placebo or vitamin C (1500 mg · l-1) beverages (2.5 ml · kg-1 body mass) every 15 min during exercise. Compared with the placebo trial, resting and post-exercise plasma vitamin C concentration and antioxidant capacity were higher and post-exercise oxidative stress markers were lower in the vitamin C trial. There was no difference between trials in the magnitude of post-exercise increases in circulating neutrophil numbers, plasma cortisol and interleukin (IL)-6 concentrations. There was a significant (2-way ANOVA) main effect of trial (P=0.039) and trialtime interaction (P=0.008) for PMA (phorbol-12-myristate-13-acetate)-stimulated chemiluminescence per neutrophil, with the post-exercise values significantly higher in the vitamin C trial (P en
dc.format.extent 11 en
dc.language.iso eng
dc.relation.ispartof European Journal of Sport Science en
dc.title The effects of acute vitamin C supplementation on cortisol, interleukin-6, and neutrophil responses to prolonged cycling exercise en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.contributor.institution Department of Sport & Exercise Science en
dc.description.status Peer reviewed en


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