Show simple item record David C. en_US Steven L. en_US Diane E. en_US 2009-11-25T16:14:42Z 2009-11-25T16:14:42Z 2001 en_US
dc.identifier en_US
dc.identifier.citation Lamb , D C , Kelly , S L & Kelly , D E 2001 , ' Genome-wide generation of yeast gene deletion strains ' Comparative and Functional Genomics , vol 2 , no. 4 , pp. 236-242 . , 10.1002/cfg.95 en_US
dc.identifier.other PURE: 130384 en_US
dc.identifier.other dspace: 2160/3635 en_US
dc.description.abstract In the year 2001 a collection of yeast strains will be completed that are deleted in the 6000 open reading frames selected as putative genes by the initial bioinformatic analysis of the Saccharomyces cerevisiae genome. The collection was produced by the transatlantic yeast gene deletion project, a collaboration involving researchers in the USA, Canada and Europe. The European effort was part of EUROFAN (European Functional Analysis Network) where some of the strains could feed into various functional analysis nodes dealing with specific areas of cell biology. With approximately 40% of human genes involved in heritable disease having a homologue in yeast and with the use of yeast in various drug discovery strategies, not least due to the dramatic increase in fungal infections, these strains will be valuable in trans-genomic studies and in specialised interest studies in individual laboratories. A detailed analysis of the project by the consortium is in preparation, here we discuss the yeast strains, reported findings and approaches to using this resource. en_US
dc.format.extent 7 en_US
dc.relation.ispartof Comparative and Functional Genomics en_US
dc.title Genome-wide generation of yeast gene deletion strains en_US
dc.contributor.pbl Aberystwyth University en_US
dc.contributor.pbl Institute of Biological, Environmental and Rural Sciences en_US

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