The cytochrome p450 complement (CYPome) of Streptomyces coelicolor A3(2)

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dc.contributor.author Kelly, Steven L.
dc.contributor.author Waterman, M. R.
dc.contributor.author Skaug, T.
dc.contributor.author Jackson, Colin J.
dc.contributor.author Kelly, Diane E.
dc.contributor.author Podust, L. M.
dc.contributor.author Kell, Douglas B.
dc.contributor.author Song, H. L.
dc.contributor.author Lamb, David C.
dc.date.accessioned 2009-11-30T16:01:39Z
dc.date.available 2009-11-30T16:01:39Z
dc.date.issued 2002-04-09
dc.identifier.citation Kelly , S L , Waterman , M R , Skaug , T , Jackson , C J , Kelly , D E , Podust , L M , Kell , D B , Song , H L & Lamb , D C 2002 , ' The cytochrome p450 complement (CYPome) of Streptomyces coelicolor A3(2) ' Journal of Biological Chemistry , vol 277 , pp. 24000-24005 . , 10.1074/jbc.M111109200 en
dc.identifier.issn 0021-9258
dc.identifier.other PURE: 131820
dc.identifier.other dspace: 2160/3746
dc.identifier.uri http://hdl.handle.net/2160/3746
dc.description Lamb, D. C., Skaug, T., Song, H. L., Jackson, C. J., Podust, L. M., Waterman, M. R., Kell, D. B., Kelly, D. E., Kelly, S. L. (2002). The cytochrome p450 complement (CYPome) of Streptomyces coelicolor A3(2).   Journal of Biological Chemistry, 277, 24000-24005. Sponsorship: BBSRC/MRC en
dc.description.abstract In the present study we describe the complete cytochrome P450 complement, the “CYPome,” of Streptomyces coelicolor A3(2). Eighteen cytochromes P450 (CYP) are described, in contrast to the absence of CYPs in Escherichia coli, and the twenty observed in Mycobacterium tuberculosis. Here we confirm protein identity as cytochromes P450 by heterologous expression in E. coli and measurement of reduced carbon monoxide difference spectra. We also report on their arrangement in the linear chromosome and relatedness to other CYPs in the superfamily. The future development of manipulation of antibiotic pathways and the use of streptomycetes in bioremediation and biotransformations will involve many of the new CYP forms identified here. en
dc.format.extent 6 en
dc.language.iso eng
dc.relation.ispartof Journal of Biological Chemistry en
dc.title The cytochrome p450 complement (CYPome) of Streptomyces coelicolor A3(2) en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1074/jbc.M111109200
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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