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dc.contributor.author Worgan, Hilary
dc.contributor.author Macías, B.
dc.contributor.author Cuervo-Arango, J.
dc.contributor.author Nash, Deborah M.
dc.date.accessioned 2009-11-30T16:15:33Z
dc.date.available 2009-11-30T16:15:33Z
dc.date.issued 2009-11-30
dc.identifier.citation Worgan , H , Macías , B , Cuervo-Arango , J & Nash , D M 2009 , ' Endometrial toll-like receptor 4 (TLR4) and Interleukin-8 (IL-8) expression in mares resistant (RM) or susceptible (SM) to endometritis ' . en
dc.identifier.other PURE: 150225
dc.identifier.other dspace: 2160/3750
dc.identifier.uri http://hdl.handle.net/2160/3750
dc.description Cuervo-Arango, J., Worgan, H., Macías, B., Nash, D. (2008). Endometrial toll-like receptor 4 (TLR4) and Interleukin-8 (IL-8) expression in mares resistant (RM) or susceptible (SM) to endometritis. Reproduction in Domestic Animals, 43, (5), p.75, Abstract P78. Proceedings of the 12th Annual Conference of the European Society for Domestic Animal Reproduction (ESDAR. en
dc.description.abstract Persistent uterine inflammation in the mare has been correlated to the expression of cytokines by the endometrium. Toll-like receptors (TLR) are host cell receptors for bacterial-associated molecules and play an important role in modulating immune responses by activating antigen-presenting cells. However, the role of equine endometrial cell TLR4 during post-breeding endometritis has not been determined. The aims were to: characterise TLR4 mRNA expression in the equine endometrium; establish changes in expression after insemination; determine differences in expression between mares resistant (RM) or susceptible (SM) to endometritis. Expression of the pro-inflammatory chemokine IL-8 was measured to confirm the status of an inflamed uterus. Endometrial biopsies were collected from 6 RM and 9 SM during oestrus and 24 h after infusion of frozen/ thawed spermatozoa and the mRNA expression of TLR4 and IL-8 was quantified by rt-PCR. The expression of TLR4 by SM tended to increase after insemination (4.9 ± 2.3-fold increase, p = 0.06) whereas expression did not differ after insemination of RM (0.61 ± 0.27-fold reduction, p > 0.05). IL-8 expression increased after insemination in SM but not in RM (3.11 ± 1.52-fold increase, p = 0.05; 1.2 ± 0.5-fold increase, p > 0.05, respectively). Endometrial TLR4 expression appeared to increase after insemination in SM. TLR4 may be important in the development of persistent inflammation in mares susceptible to endometritis en
dc.language.iso eng
dc.title Endometrial toll-like receptor 4 (TLR4) and Interleukin-8 (IL-8) expression in mares resistant (RM) or susceptible (SM) to endometritis en
dc.type Text en
dc.type.publicationtype Conference paper en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Non peer reviewed en


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