N- and O-alkylation of isoquinolin-1-ones in the Mitsunobu reaction: Development of potential drug delivery systems

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dc.contributor.author Threadgill, Michael D.
dc.contributor.author Ferrer, Sandra
dc.contributor.author Naughton, Declan P.
dc.contributor.author Parveen, Ifat
dc.date.accessioned 2009-12-15T09:18:08Z
dc.date.available 2009-12-15T09:18:08Z
dc.date.issued 2002
dc.identifier.citation Threadgill , M D , Ferrer , S , Naughton , D P & Parveen , I 2002 , ' N- and O-alkylation of isoquinolin-1-ones in the Mitsunobu reaction: Development of potential drug delivery systems ' Journal of the Chemical Society, Perkin Transactions 1 , pp. 335-340 . , 10.1039/b109776h en
dc.identifier.issn 1364-5463
dc.identifier.other PURE: 133870
dc.identifier.other dspace: 2160/3823
dc.identifier.uri http://hdl.handle.net/2160/3823
dc.description Ferrer, S., Naughton, D. P., Parveen, I., Threadgill, M. D. (2002). N- and O-alkylation of isoquinolin-1-ones in the Mitsunobu reaction: Development of potential drug delivery systems.   Journal of the Chemical Society, Perkin Transactions 1, 3, 335-340 Sponsorship: Association for International Cancer Research en
dc.description.abstract Regioselective methods were investigated to prepare N- and O-alkylated isoquinolin-1-ones efficiently. The predicted regioselective alkylation of the nitrogen with (hetero)benzyl halides was complemented using (hetero)benzylic Mitsunobu electrophiles to alkylate predominantly at the oxygen. A series of drug-delivery conjugates was prepared demonstrating control over the site of alkylation. The Mitsunobu reaction provides a new approach to 1-alkoxyisoquinolines that were unavailable via previous harsher synthetic methods. en
dc.format.extent 6 en
dc.language.iso eng
dc.relation.ispartof Journal of the Chemical Society, Perkin Transactions 1 en
dc.title N- and O-alkylation of isoquinolin-1-ones in the Mitsunobu reaction: Development of potential drug delivery systems en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1039/b109776h
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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