Molecular basis of resistance to azole antifungals

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dc.contributor.author Lupetti, Antonella
dc.contributor.author Danesi, Romano
dc.contributor.author Campa, Mario
dc.contributor.author Del Tacca, Mario
dc.contributor.author Kelly, Steven L.
dc.date.accessioned 2009-12-15T14:43:07Z
dc.date.available 2009-12-15T14:43:07Z
dc.date.issued 2002
dc.identifier.citation Lupetti , A , Danesi , R , Campa , M , Del Tacca , M & Kelly , S L 2002 , ' Molecular basis of resistance to azole antifungals ' Trends in Molecular Medicine , vol 8 , no. 2 , pp. 76-81 . en
dc.identifier.other PURE: 134338
dc.identifier.other dspace: 2160/3827
dc.identifier.uri http://hdl.handle.net/2160/3827
dc.description Lupetti, A., Danesi, R., Campa, M., Del Tacca, M., Kelly, S. (2002). Molecular basis of resistance to azole antifungals.   Trends in Molecular Medicine, 8, (2), 76-81 en
dc.description.abstract The increased incidence of invasive mycoses and the emerging problem of antifungal drug resistance has prompted investigations of the underlying molecular mechanisms, particularly for the azole compounds central to current therapy. The target site for the azoles is the ERG11 gene product, the cytochrome P450 lanosterol 14α-demethylase, which is part of the ergosterol biosynthetic pathway. The resulting ergosterol depletion renders fungal cells vulnerable to further membrane damage. Development of azole resistance in fungi may occur through increased levels of the cellular target, upregulation of genes controlling drug efflux, alterations in sterol synthesis and decreased affinity of azoles for the cellular target. Here, we review the adaptative changes in fungi, in particular Candida albicans, in response to inhibitors of ergosterol biosynthesis. The molecular mechanisms of azole resistance might help in devising more effective antifungal therapies. en
dc.format.extent 6 en
dc.language.iso eng
dc.relation.ispartof Trends in Molecular Medicine en
dc.title Molecular basis of resistance to azole antifungals en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1016/S1471-4914(02)02280-3
dc.contributor.institution Aberystwyth University en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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