Extreme population dependent linkage disequilibrium detected in an inbreeding plant species, Hordeum vulgare

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dc.contributor.author Russell, Joanne
dc.contributor.author Powell, Wayne
dc.contributor.author Caldwell, Katherine S.
dc.contributor.author Langridge, Peter
dc.date.accessioned 2009-12-22T14:57:28Z
dc.date.available 2009-12-22T14:57:28Z
dc.date.issued 2006
dc.identifier.citation Russell , J , Powell , W , Caldwell , K S & Langridge , P 2006 , ' Extreme population dependent linkage disequilibrium detected in an inbreeding plant species, Hordeum vulgare ' Genetics , vol 172 , no. 1 , pp. 557-567 . en
dc.identifier.issn 0016-6731
dc.identifier.other PURE: 141789
dc.identifier.other dspace: 2160/3892
dc.identifier.uri http://hdl.handle.net/2160/3892
dc.description Caldwell, K. S., Russell, J., Langridge, P., Powell, W. (2006). Extreme population dependent linkage disequilibrium detected in an inbreeding plant species, Hordeum vulgare.  Genetics, 172, (1), 557-567 Sponsorship: SEERAD en
dc.description.abstract In human genetics a detailed knowledge of linkage disequilibrium (LD) is considered a prerequisite for effective population-based, high-resolution gene mapping and cloning. Similar opportunities exist for plants; however, differences in breeding system and population history need to be considered. Here we report a detailed study of localized LD in different populations of an inbreeding crop species. We measured LD between and within four gene loci within the region surrounding the hardness locus in three different gene pools of barley (Hordeum vulgare). We demonstrate that LD extends to at least 212 kb in elite barley cultivars but is rapidly eroded in related inbreeding ancestral populations. Our results indicate that haplotype-based sequence analysis in multiple populations will provide new opportunities to adjust the resolution of association studies in inbreeding crop species. en
dc.format.extent 11 en
dc.language.iso eng
dc.relation.ispartof Genetics en
dc.title Extreme population dependent linkage disequilibrium detected in an inbreeding plant species, Hordeum vulgare en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1534/genetics.104.038489
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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