Show simple item record Richards, R. G. Frauchiger, V. Baxter, L. C. ap Gwynn, Iolo A. Textor, M. 2009-12-23T10:11:51Z 2009-12-23T10:11:51Z 2002
dc.identifier.citation Richards , R G , Frauchiger , V , Baxter , L C , ap Gwynn , I A & Textor , M 2002 , ' Fibroblast and osteoblast adhestion and morphology on calcium phosphate surfaces ' European Cells and Materials , vol 4 , no. 1-17 , pp. 1-17 . en
dc.identifier.other PURE: 132801
dc.identifier.other PURE UUID: 75ea2ae0-859e-43c7-a257-1b11b92c5ab0
dc.identifier.other dspace: 2160/3908
dc.identifier.uri en
dc.description Baxter, L. C., Frauchiger, V., Textor, M., ap Gwynn, I., Richards, R. G. (2002). Fibroblast and osteoblast adhestion and morphology on calcium phosphate surfaces. European Cells and Materials, 4, 1-17. Sponsorship: KTI MedTech (grant number 4729.1), Robert Mathys Foundation and Stratec Medical. en
dc.description.abstract Implant loosening in bone fixation is an unresolved complication associated with internal fixation. It is generally accepted that this problem can be overcome by modifying the implant/bone interface for improved osseointegration. This is achieved, in part, by hydroxyapatite (HA) or tricalcium phosphate coatings. Unfortunately, the benefits of these coatings are constrained by not only the generally low strength of their adhesion to the implant surface but also the limited cohesion within their layers. Anodic Plasmachemical treatment (APC) has been developed to incorporate electrolytes and produce coatings with various microtopographies and strong adhesion to implants. In this in vitro study fibroblast and osteoblast morphologies and adhesion to various substrates were evaluated using qualitative and quantitative methods. The substrates were Thermanox plastic and commercially pure titanium. The latter were surface-treated using several different methods: conventional anodisation, plasma spraying of HA and anodic plasma-chemical (APC) treatment in an electrolyte solution containing either calcium and phosphate (APCCaP) or phosphoric acid (APC-P). Both osteoblasts and fibroblasts showed extensive cell spreading, total cell area and greatest amount of adhesion, with defined adhesion patterns on the Thermanox plastic, anodised titanium, and the two APC-CaP substrates. With fibroblasts, almost no cell spreading and very low adhesion, was observed in cells cultured on the APC-P and HA surfaces. The extent of cell spreading correlated with the area of focal adhesions as assessed by the amount of vinculin labelling. The Thermanox plastic, anodised titanium, and the two APCCaP substrates were the most cytocompatible substrates with regard to this in vitro evaluation. en
dc.format.extent 17 en
dc.language.iso eng
dc.relation.ispartof European Cells and Materials en
dc.rights en
dc.title Fibroblast and osteoblast adhestion and morphology on calcium phosphate surfaces en
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article en
dc.contributor.institution Department of Geography and Earth Sciences en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en

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