| dc.contributor.author |
Kell, Douglas B. |
|
| dc.contributor.author |
Pritchard, Leighton |
|
| dc.date.accessioned |
2010-01-07T10:28:36Z |
|
| dc.date.available |
2010-01-07T10:28:36Z |
|
| dc.date.issued |
2002-08-05 |
|
| dc.identifier.citation |
Kell , D B & Pritchard , L 2002 , ' Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis ' European Journal of Biochemistry , vol 269 , no. 16 , pp. 3894-3904 . |
en |
| dc.identifier.issn |
1742-4658 |
|
| dc.identifier.other |
PURE: 134695 |
|
| dc.identifier.other |
dspace: 2160/3945 |
|
| dc.identifier.uri |
http://hdl.handle.net/2160/3945 |
|
| dc.description |
Pritchard, L., Kell, D. B. (2002). Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis. European Journal of Biochemistry, 269, (16), 3894-3904. |
en |
| dc.description.abstract |
We used parameter scanning to emulate changes to the limiting rate for steps in a fitted model of glucose-derepressed yeast glycolysis. Three flux-control regimes were observed, two of which were under the dominant control of hexose transport, in accordance with various experimental studies and other model predictions. A third control regime in which phosphofructokinase exerted dominant glycolytic flux control was also found, but it appeared to be physiologically unreachable by this model, and all realistically obtainable flux control regimes featured hexose transport as a step involving high flux control. |
en |
| dc.format.extent |
11 |
en |
| dc.language.iso |
eng |
|
| dc.relation.ispartof |
European Journal of Biochemistry |
en |
| dc.title |
Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis |
en |
| dc.type |
Text |
en |
| dc.type.publicationtype |
Article (Journal) |
en |
| dc.identifier.doi |
http://dx.doi.org/10.1046/j.1432-1033.2002.03055.x |
|
| dc.contributor.institution |
Aberystwyth University |
en |
| dc.contributor.institution |
Institute of Biological, Environmental and Rural Sciences |
en |
| dc.description.status |
Peer reviewed |
en |