Explanatory optimization of protein mass spectrometry via genetic search

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dc.contributor.author Goodacre, Royston
dc.contributor.author Vaidyanathan, S.
dc.contributor.author Broadhurst, David I.
dc.contributor.author Kell, Douglas B.
dc.date.accessioned 2010-03-03T12:16:33Z
dc.date.available 2010-03-03T12:16:33Z
dc.date.issued 2003-10-25
dc.identifier.citation Goodacre , R , Vaidyanathan , S , Broadhurst , D I & Kell , D B 2003 , ' Explanatory optimization of protein mass spectrometry via genetic search ' Analytical Chemistry , pp. 6679-6686 . en
dc.identifier.issn 1520-6882
dc.identifier.other PURE: 136398
dc.identifier.other dspace: 2160/4146
dc.identifier.uri http://hdl.handle.net/2160/4146
dc.description Vaidyanathan, S., Broadhurst, D. I., Kell, D. B., Goodacre, R. (2003). Explanatory optimization of protein mass spectrometry via genetic search. Analytical Chemistry, 75, (23), 6679-6686. Sponsorship: BBSRC/EPSRC en
dc.description.abstract Optimizing experimental conditions for the effective analysis of intact proteins by mass spectrometry is challenging, as many analytical factors influence the spectral quality, often in very different ways for different proteins and especially with complex protein mixtures. We show that genetic search methods are highly effective in this kind of optimization and that it was possible in 6 generations with a total of en
dc.format.extent 8 en
dc.language.iso eng
dc.relation.ispartof Analytical Chemistry en
dc.title Explanatory optimization of protein mass spectrometry via genetic search en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1021/ac034669a
dc.contributor.institution Aberystwyth University en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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