Abstract:
The synthesis of a range of cyclic guanidines via intramolecular ring opening of epoxides or iodocyclisation is reported. A preliminary investigation of the glycosidase inhibitory activity of these substances is also discussed. The synthesis of a range of cyclic guanidines via intramolecular ring opening of epoxides or iodocyclisation is reported, together with a preliminary investigation of the glycosidase inhibitory activity of these substances.
Description:
Dennis, M., Hall, L. M., Murphy. P. J., Thornhill, A. J., Nash, R., Winters, A. L., Hursthouse, M. B., Light, M. E., Horton, P. (2003). Intramolecular guanidine epoxide ring opening reactions. Tetrahedron Letters, 44, (15), 3075-3080. Sponsorship: EPSRC