Show simple item record Atsushi en_US Kyoko en_US Alison A. en_US M. en_US Y. en_US Naoki en_US Robert J. en_US R. J. en_US S. L. en_US 2010-03-04T15:50:32Z 2010-03-04T15:50:32Z 2003-07-11 en_US
dc.identifier en_US
dc.identifier.citation Kato , A , Ikeda , K , Watson , A A , Haraguchi , M , Minami , Y , Asano , N , Nash , R J , Molyneux , R J & Gorniak , S L 2003 , ' Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae) ' Journal of Agricultural and Food Chemistry , vol 51 , no. 17 , pp. 4995-5000 . , 10.1021/jf0341722 en_US
dc.identifier.other PURE: 137489 en_US
dc.identifier.other dspace: 2160/4171 en_US
dc.description.abstract Natural intoxication of livestock by the ingestion of Ipomoea carnea (Convolvulaceae) sometimes occurs in tropical regions of the world. Polyhydroxylated alkaloids were isolated from the leaves, flowers, and seeds of the poisonous plant and characterized. Chromatographic separation of the leaf extract resulted in the isolation of swainsonine (1), 2-epi-lentiginosine (2), calystegines B1 (3), B2 (4), B3 (5), and C1 (6), and N-methyl-trans-4-hydroxy-l-proline (7). The contents of 1 in the fresh leaves and flowers were 0.0029 and 0.0028%, respectively, whereas the contents of 1, 3, and 4 in the seeds were 10 times higher than those in the leaves and flowers. Alkaloids 3, 4, and 6 showed a potent inhibitory activity toward rat lysosomal β-glucosidase, with IC50 values of 2.1, 0.75, and 0.84 μM, respectively, and alkaloid 5 was a moderate inhibitor of α- and β-mannosidases. Although alkaloid 1 is known as a powerful inhibitor of lysosomal α-mannosidase (IC50 = 0.02 μM), alkaloid 2, which has been thought to be an intermediate in the biosynthesis of 1, was also a potent inhibitor of α-mannosidase with an IC50 value of 4.6 μM. en_US
dc.format.extent 6 en_US
dc.relation.ispartof Journal of Agricultural and Food Chemistry en_US
dc.title Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae) en_US
dc.contributor.pbl Aberystwyth University en_US
dc.contributor.pbl Institute of Biological, Environmental and Rural Sciences en_US

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