Show simple item record Haraguchi, Mitsue Gorniak, Silvana L. Ikeda, Kyoko Minami, Yasuhiro Kato, Atsushi Watson, Alison A. Nash, Robert J. Molyneux, Russell J. Asano, Naoki 2010-03-04T15:50:32Z 2010-03-04T15:50:32Z 2003-07-11
dc.identifier.citation Haraguchi , M , Gorniak , S L , Ikeda , K , Minami , Y , Kato , A , Watson , A A , Nash , R J , Molyneux , R J & Asano , N 2003 , ' Alkaloidal Components in the Poisonous Plant, Ipomoea carnea (Convolvulaceae) ' Journal of Agricultural and Food Chemistry , vol 51 , no. 17 , pp. 4995-5000 . DOI: 10.1021/jf0341722 en
dc.identifier.issn 0021-8561
dc.identifier.other PURE: 137489
dc.identifier.other PURE UUID: d59de137-1180-4267-9f48-770a3ca57f9d
dc.identifier.other dspace: 2160/4171
dc.identifier.other DSpace_20121128.csv: row: 3114
dc.identifier.other Scopus: 0042061140
dc.identifier.other PubMed: 12903959
dc.description Haraguchi, M., Gorniak, S. L., Ikeda, K., Minami, Y., Kato, A., Watson, A. A., Nash, R. J., Molyneux, R. J., Asano, N. (2003). Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae).   Journal of Agricultural and Food Chemistry, 51, (17), 4995-5000. en
dc.description.abstract Natural intoxication of livestock by the ingestion of Ipomoea carnea (Convolvulaceae) sometimes occurs in tropical regions of the world. Polyhydroxylated alkaloids were isolated from the leaves, flowers, and seeds of the poisonous plant and characterized. Chromatographic separation of the leaf extract resulted in the isolation of swainsonine (1), 2-epi-lentiginosine (2), calystegines B1 (3), B2 (4), B3 (5), and C1 (6), and N-methyl-trans-4-hydroxy-l-proline (7). The contents of 1 in the fresh leaves and flowers were 0.0029 and 0.0028%, respectively, whereas the contents of 1, 3, and 4 in the seeds were ∼10 times higher than those in the leaves and flowers. Alkaloids 3, 4, and 6 showed a potent inhibitory activity toward rat lysosomal β-glucosidase, with IC50 values of 2.1, 0.75, and 0.84 μM, respectively, and alkaloid 5 was a moderate inhibitor of α- and β-mannosidases. Although alkaloid 1 is known as a powerful inhibitor of lysosomal α-mannosidase (IC50 = 0.02 μM), alkaloid 2, which has been thought to be an intermediate in the biosynthesis of 1, was also a potent inhibitor of α-mannosidase with an IC50 value of 4.6 μM. en
dc.format.extent 6 en
dc.language.iso eng
dc.relation.ispartof Journal of Agricultural and Food Chemistry en
dc.rights en
dc.subject Ipomoea carnea en
dc.subject poisonous plant en
dc.subject intoxication in livestock en
dc.subject polyhydroxylated alkaloids en
dc.subject glycosidase inhibition en
dc.title Alkaloidal Components in the Poisonous Plant, Ipomoea carnea (Convolvulaceae) en
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en

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