Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae)

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dc.contributor.author Kato, Atsushi
dc.contributor.author Ikeda, Kyoko
dc.contributor.author Watson, Alison A.
dc.contributor.author Haraguchi, M.
dc.contributor.author Minami, Y.
dc.contributor.author Asano, Naoki
dc.contributor.author Nash, Robert J.
dc.contributor.author Molyneux, R. J.
dc.contributor.author Gorniak, S. L.
dc.date.accessioned 2010-03-04T15:50:32Z
dc.date.available 2010-03-04T15:50:32Z
dc.date.issued 2003-07-11
dc.identifier.citation Kato , A , Ikeda , K , Watson , A A , Haraguchi , M , Minami , Y , Asano , N , Nash , R J , Molyneux , R J & Gorniak , S L 2003 , ' Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae) ' Journal of Agricultural and Food Chemistry , vol 51 , no. 17 , pp. 4995-5000 . , 10.1021/jf0341722 en
dc.identifier.issn 0021-8561
dc.identifier.other PURE: 137489
dc.identifier.other dspace: 2160/4171
dc.identifier.uri http://hdl.handle.net/2160/4171
dc.description Haraguchi, M., Gorniak, S. L., Ikeda, K., Minami, Y., Kato, A., Watson, A. A., Nash, R. J., Molyneux, R. J., Asano, N. (2003). Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae).   Journal of Agricultural and Food Chemistry, 51, (17), 4995-5000. en
dc.description.abstract Natural intoxication of livestock by the ingestion of Ipomoea carnea (Convolvulaceae) sometimes occurs in tropical regions of the world. Polyhydroxylated alkaloids were isolated from the leaves, flowers, and seeds of the poisonous plant and characterized. Chromatographic separation of the leaf extract resulted in the isolation of swainsonine (1), 2-epi-lentiginosine (2), calystegines B1 (3), B2 (4), B3 (5), and C1 (6), and N-methyl-trans-4-hydroxy-l-proline (7). The contents of 1 in the fresh leaves and flowers were 0.0029 and 0.0028%, respectively, whereas the contents of 1, 3, and 4 in the seeds were 10 times higher than those in the leaves and flowers. Alkaloids 3, 4, and 6 showed a potent inhibitory activity toward rat lysosomal β-glucosidase, with IC50 values of 2.1, 0.75, and 0.84 μM, respectively, and alkaloid 5 was a moderate inhibitor of α- and β-mannosidases. Although alkaloid 1 is known as a powerful inhibitor of lysosomal α-mannosidase (IC50 = 0.02 μM), alkaloid 2, which has been thought to be an intermediate in the biosynthesis of 1, was also a potent inhibitor of α-mannosidase with an IC50 value of 4.6 μM. en
dc.format.extent 6 en
dc.language.iso eng
dc.relation.ispartof Journal of Agricultural and Food Chemistry en
dc.title Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae) en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1021/jf0341722
dc.contributor.institution Aberystwyth University en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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