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dc.contributor.author Atsushi en_US
dc.contributor.author Kyoko en_US
dc.contributor.author Alison A. en_US
dc.contributor.author M. en_US
dc.contributor.author Y. en_US
dc.contributor.author Naoki en_US
dc.contributor.author Robert J. en_US
dc.contributor.author R. J. en_US
dc.contributor.author S. L. en_US
dc.date.accessioned 2010-03-04T15:50:32Z
dc.date.available 2010-03-04T15:50:32Z
dc.date.issued 2003-07-11 en_US
dc.identifier http://dx.doi.org/10.1021/jf0341722 en_US
dc.identifier.citation Kato , A , Ikeda , K , Watson , A A , Haraguchi , M , Minami , Y , Asano , N , Nash , R J , Molyneux , R J & Gorniak , S L 2003 , ' Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae) ' Journal of Agricultural and Food Chemistry , vol 51 , no. 17 , pp. 4995-5000 . , 10.1021/jf0341722 en_US
dc.identifier.other PURE: 137489 en_US
dc.identifier.other dspace: 2160/4171 en_US
dc.identifier.uri http://hdl.handle.net/2160/4171
dc.description.abstract Natural intoxication of livestock by the ingestion of Ipomoea carnea (Convolvulaceae) sometimes occurs in tropical regions of the world. Polyhydroxylated alkaloids were isolated from the leaves, flowers, and seeds of the poisonous plant and characterized. Chromatographic separation of the leaf extract resulted in the isolation of swainsonine (1), 2-epi-lentiginosine (2), calystegines B1 (3), B2 (4), B3 (5), and C1 (6), and N-methyl-trans-4-hydroxy-l-proline (7). The contents of 1 in the fresh leaves and flowers were 0.0029 and 0.0028%, respectively, whereas the contents of 1, 3, and 4 in the seeds were 10 times higher than those in the leaves and flowers. Alkaloids 3, 4, and 6 showed a potent inhibitory activity toward rat lysosomal β-glucosidase, with IC50 values of 2.1, 0.75, and 0.84 μM, respectively, and alkaloid 5 was a moderate inhibitor of α- and β-mannosidases. Although alkaloid 1 is known as a powerful inhibitor of lysosomal α-mannosidase (IC50 = 0.02 μM), alkaloid 2, which has been thought to be an intermediate in the biosynthesis of 1, was also a potent inhibitor of α-mannosidase with an IC50 value of 4.6 μM. en_US
dc.format.extent 6 en_US
dc.relation.ispartof Journal of Agricultural and Food Chemistry en_US
dc.title Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae) en_US
dc.contributor.pbl Aberystwyth University en_US
dc.contributor.pbl Institute of Biological, Environmental and Rural Sciences en_US


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