Hierarchical metabolomics demonstrates substantial compositional similarity between genetically-modified and conventional potato crops

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dc.contributor.author Catchpole, Gareth
dc.contributor.author Beckmann, Manfred
dc.contributor.author Enot, David Pierre Louis
dc.contributor.author Mondhe, Madhav
dc.contributor.author Zywicki, Britta
dc.contributor.author Taylor, Janet
dc.contributor.author Hardy, Nigel William
dc.contributor.author Smith, Aileen Roberta
dc.contributor.author King, Ross Donald
dc.contributor.author Kell, Douglas B.
dc.contributor.author Fiehn, Oliver
dc.contributor.author Draper, John
dc.date.accessioned 2010-03-10T14:03:45Z
dc.date.available 2010-03-10T14:03:45Z
dc.date.issued 2005-10-04
dc.identifier.citation Catchpole , G , Beckmann , M , Enot , D P L , Mondhe , M , Zywicki , B , Taylor , J , Hardy , N W , Smith , A R , King , R D , Kell , D B , Fiehn , O & Draper , J 2005 , ' Hierarchical metabolomics demonstrates substantial compositional similarity between genetically-modified and conventional potato crops ' Proceedings of the National Academy of Sciences , vol 102 , no. 40 , pp. 14458-14462 . , 10.1073/pnas.0503955102 en
dc.identifier.issn 1091-6490
dc.identifier.other PURE: 118273
dc.identifier.other dspace: 2160/4228
dc.identifier.uri http://hdl.handle.net/2160/4228
dc.description Catchpole, G. S., Beckmann, M., Enot, D. P., Mondhe, M., Zywicki, B., Taylor, J., Hardy, N., Smith, A., King, R. D., Kell, D. B., Fiehn, O., Draper, J. (2005). Hierarchical metabolomics demonstrates substantial compositional similarity between genetically-modified and conventional potato crops.   Proceedings of the National Academy of Science USA, 102 (40), 14458-14462. Sponsorship: Food Standards Agency (London) en
dc.description.abstract There is current debate whether genetically modified (GM) plants might contain unexpected, potentially undesirable changes in overall metabolite composition. However, appropriate analytical technology and acceptable metrics of compositional similarity require development. We describe a comprehensive comparison of total metabolites in field-grown GM and conventional potato tubers using a hierarchical approach initiating with rapid metabolome “fingerprinting” to guide more detailed profiling of metabolites where significant differences are suspected. Central to this strategy are data analysis procedures able to generate validated, reproducible metrics of comparison from complex metabolome data. We show that, apart from targeted changes, these GM potatoes in this study appear substantially equivalent to traditional cultivars. en
dc.format.extent 5 en
dc.language.iso eng
dc.relation.ispartof Proceedings of the National Academy of Sciences en
dc.subject genetically modified substantial equivalence machine learning en
dc.title Hierarchical metabolomics demonstrates substantial compositional similarity between genetically-modified and conventional potato crops en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1073/pnas.0503955102
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.contributor.institution Department of Computer Science en
dc.description.status Peer reviewed en


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