Measurement of dietary exposure: a challenging problem which may be overcome thanks to metabolomics?

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dc.contributor.author Favé, Gaëlle
dc.contributor.author Beckmann, Manfred
dc.contributor.author Draper, John
dc.contributor.author Mathers, John C.
dc.date.accessioned 2010-03-19T09:35:42Z
dc.date.available 2010-03-19T09:35:42Z
dc.date.issued 2009-06-01
dc.identifier.citation Favé , G , Beckmann , M , Draper , J & Mathers , J C 2009 , ' Measurement of dietary exposure: a challenging problem which may be overcome thanks to metabolomics? ' Genes and Nutrition , vol 4 , no. 2 , pp. 135-141 . en
dc.identifier.issn 1865-3499
dc.identifier.other PURE: 145479
dc.identifier.other dspace: 2160/4487
dc.identifier.uri http://hdl.handle.net/2160/4487
dc.identifier.uri http://www.springerlink.com/content/157113038u310886/fulltext.pdf en
dc.description Favé, G., Beckmann, M. E., Draper, J. H., Mathers, J. C. (2009). Measurement of dietary exposure: a challenging problem which may be overcome thanks to metabolomics? Genes and Nutrition, 4 (2), 135-141. IMPF: 01.11 Sponsorship: UK Food Standard Agency N05073 en
dc.description.abstract The diet is an important environmental exposure, and its measurement is an essential component of much health-related research. However, conventional tools for measuring dietary exposure have significant limitations being subject to an unknown degree of misreporting and dependent upon food composition tables to allow estimation of intakes of energy, nutrients and non-nutrient food constituents. In addition, such tools may be inappropriate for use with certain groups of people. As an alternative approach, the recent techniques of metabolite profiling or fingerprinting, which allows simultaneous monitoring of multiple and dynamic components of biological fluids, may provide metabolic signals indicative of food intake. Samples can be analysed through numerous analytical platforms, followed by multivariate data analysis. In humans, metabolomics has been applied successfully in pharmacology, toxicology and medical screening, but nutritional metabolomics is still in its infancy. Biomarkers of a small number of specific foods and nutrients have been developed successfully but less targeted and more high-throughput methods, that do not need prior knowledge of which signals might be discriminatory, and which may allow a more global characterisation of dietary intake, remain to be tested. A proof a principle project (the MEDE Study) is currently underway in our laboratories to test the hypothesis that high-throughput, non-targeted metabolite fingerprinting using flow injection electrospray mass spectrometry can be applied to human biofluids (blood and urine) to characterise dietary exposure in humans. en
dc.format.extent 7 en
dc.language.iso eng
dc.relation.ispartof Genes and Nutrition en
dc.subject Dietary exposure en
dc.subject Human studies en
dc.subject Mass spectrometry en
dc.subject Metabolite fingerprinting en
dc.subject Nutritional metabolomics en
dc.subject Multivariate supervised classifications en
dc.title Measurement of dietary exposure: a challenging problem which may be overcome thanks to metabolomics? en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1007/s12263-009-0120-y
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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